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Titolo:
On the theoretical basis of perfusion measurements by dynamic susceptibility contrast MRI
Autore:
Kiselev, VG;
Indirizzi:
Univ Hosp Freiburg, Sect Med Phys, Dept Diagnost Radiol, D-79106 Freiburg,Germany Univ Hosp Freiburg Freiburg Germany D-79106 ol, D-79106 Freiburg,Germany
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 6, volume: 46, anno: 2001,
pagine: 1113 - 1122
SICI:
0740-3194(200112)46:6<1113:OTTBOP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON-EMISSION-TOMOGRAPHY; HIGH-RESOLUTION MEASUREMENT; IMAGING BOLUS TRACKING; PASSAGES; NETWORK; TIME;
Keywords:
perfusion imaging; dynamic MRI; bolus tracking; T-2 contrast; susceptibility contrast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kiselev, VG Univ Hosp Freiburg, Sect Med Phys, Dept Diagnost Radiol, Hugstetterstr 55,D-79106 Freiburg, Germany Univ Hosp Freiburg Hugstetterstr 55 Freiburg Germany D-79106
Citazione:
V.G. Kiselev, "On the theoretical basis of perfusion measurements by dynamic susceptibility contrast MRI", MAGN RES M, 46(6), 2001, pp. 1113-1122

Abstract

A quantitative analysis was undertaken to calibrate the perfusion quantification technique based on tracking the first pass of a bolus of a blood pool contrast agent. A complete simulation of the bolus passage, of the associated changes in the T-2 and T-2(*) signals, and of the data processing was performed using the tracer dilution theory, an analytical theory of the MR signal from living tissues and numerical simulations. The noise was excluded in the simulation in order to analyze the ultimate accuracy of the method. It is demonstrated that the relationship between the contrast agent concentration and the associated changes in the transverse relaxation rate showsessentially different forms in studied tissue and in the reference artery. This effect results in systematic deviations of the measured blood flow, blood volume, and the residue function obtained with conventional processingfrom their true values. The error depends on the microvascular composition, the properties of the contrast agent, and the weights of the various compartments in the total signal. The results show that dynamic susceptibility contrast MRI can reach the goal of absolute perfusion quantification only with additional input from measurements of the microvascular architecture. Alternatively, the method can be used to provide such information if the perfusion is quantified by another modality. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:08:05