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Titolo:
A synopsis of the clinical uses of argatroban
Autore:
Moledina, M; Chakir, M; Gandhi, PJ;
Indirizzi:
Massachusetts Coll Pharm & Hlth Sci Worcester, Dept Pharm Practice, Worcester, MA 01608 USA Massachusetts Coll Pharm & Hlth Sci Worcester Worcester MA USA 01608 USA
Titolo Testata:
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
fascicolo: 2, volume: 12, anno: 2001,
pagine: 141 - 149
SICI:
0929-5305(200110)12:2<141:ASOTCU>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPARIN-INDUCED THROMBOCYTOPENIA; SYNTHETIC THROMBIN INHIBITOR; CORONARY STENT IMPLANTATION; CEREBRAL THROMBOSIS; ANTITHROMBIN-III; ANTICOAGULATION; PATIENT; ANGIOPLASTY; INTERVENTIONS; PHARMACOLOGY;
Keywords:
argatroban; heparin-induced thrombocytopenia; direct thrombin inhibitors; MD-805;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Gandhi, PJ Massachusetts Coll Pharm & Hlth Sci Worcester, Dept Pharm Practice, 19 Foster St, Worcester, MA 01608 USA Massachusetts Coll Pharm & Hlth Sci Worcester 19 Foster St Worcester MA USA 01608
Citazione:
M. Moledina et al., "A synopsis of the clinical uses of argatroban", J THROMB TH, 12(2), 2001, pp. 141-149

Abstract

Argatroban, a direct thrombin inhibitor, has been used in Japan since the early 1980's and was recently approved for use in the United States for patients with heparin-induced thrombocytopenia. However, its use has been studied in other clinical settings including, myocardial infarction, percutaneous coronary intervention and cerebral thrombosis. The doses used in the different clinical situations vary, but argatroban offers the advantage of notrequiring renal adjustment. Because of its small molecular weight, argatroban has the ability to inhibit both clot bound and soluble thrombin. This paper provides a comprehensive review of both indicated and off label uses of argatroban. Pharmacology, pharmacokinetics, adverse events and drug interactions with argatroban are also discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:00:13