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Titolo:
Meningitis due to penicillin-resistant Neisseria meningitidis in a 20-year-old man
Autore:
Ben, RJ; Wang, CC; Chu, ML;
Indirizzi:
Armed Forces Kaohsiung Gen Hosp, Dept Med, Div Infect Dis, Kaohsiung, Taiwan Armed Forces Kaohsiung Gen Hosp Kaohsiung Taiwan Dis, Kaohsiung, Taiwan Tri Serv Gen Hosp, Dept Pediat, Kaohsiung, Taiwan Tri Serv Gen Hosp Kaohsiung Taiwan Hosp, Dept Pediat, Kaohsiung, Taiwan
Titolo Testata:
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
fascicolo: 10, volume: 100, anno: 2001,
pagine: 696 - 698
SICI:
0929-6646(200110)100:10<696:MDTPNM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSCEPTIBILITY TEST; UNITED-STATES; MENINGOCOCCI;
Keywords:
penicillin; resistance; minimal inhibitory concentration; meningitis; Neisseria meningitidis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Ben, RJ Armed Forces Kaohsiung Gen Hosp, Dept Med, Div Infect Dis, 2 ChungCheng 1st Rd, Kaohsiung, Taiwan Armed Forces Kaohsiung Gen Hosp 2 Chung Cheng 1st Rd Kaohsiung Taiwan
Citazione:
R.J. Ben et al., "Meningitis due to penicillin-resistant Neisseria meningitidis in a 20-year-old man", J FORMOS ME, 100(10), 2001, pp. 696-698

Abstract

The emergence of meningococcal strains with reduced susceptibility to penicillin has been reported in several countries during the past two decades, but not in Taiwan. We report a case of meningococcal meningitis with intermediate resistance to penicillin. A 20-year-old male soldier complained of chills, fever, and headache for 2 days, followed by drowsiness. Physical examination revealed er erythema of the pharynx, stiff neck, erythematous maculopapules, and petechiae over the trunk and four limbs including palms and soles. Analysis of the cerebrospinal fluid (CSF) showed a white blood cell count of 9.06 x 10(6)/L, a glucose concentration of 0.165 mmol/L, and a protein concentration of 7.85 g/L. CSF Culture yielded Neisseria meningitidis,serogroup B. The minimum inhibitory concentration of penicillin was determined using an E-test (0.125 mug/mL); there was no beta -lactamase production. He recovered after high-dose penicillin G treatment with six doses of 24million units per clay for 11 days. The emergence of penicillin resistancein X. meningitidis in Taiwan requires surveillance. high-close penicillin may be successful in treating penicillin-insensitive meningococcal meningitis. Alternative,e treatment with third-generation cephalosporins should be considered if poor response to penicillin is encountered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:42:04