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Titolo:
Association of mitral annulus calcification, aortic valve sclerosis and aortic root calcification with abnormal myocardial perfusion single photon emission tomography in subjects age <= 65 years old
Autore:
Jeon, DS; Atar, S; Brasch, AV; Luo, H; Mirocha, J; Naqvi, TZ; Kraus, R; Berman, DS; Siegel, RJ;
Indirizzi:
Cedars Sinai Med Ctr, Cardiac Noninvas Lab, Div Cardiol, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 7, volume: 38, anno: 2001,
pagine: 1988 - 1993
SICI:
0735-1097(200112)38:7<1988:AOMACA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ULTRAFAST COMPUTED-TOMOGRAPHY; INCREMENTAL PROGNOSTIC VALUE; ANULAR CALCIUM; CARDIOVASCULAR MORTALITY; DIABETES-MELLITUS; ELDERLY PATIENTS; FOLLOW-UP; ANGIOGRAPHY; PREVALENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Siegel, RJ Cedars Sinai Med Ctr, Cardiac Noninvas Lab, Div Cardiol, Room 5335, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Room 5335 Los Angeles CA USA 90048 048 USA
Citazione:
D.S. Jeon et al., "Association of mitral annulus calcification, aortic valve sclerosis and aortic root calcification with abnormal myocardial perfusion single photon emission tomography in subjects age <= 65 years old", J AM COL C, 38(7), 2001, pp. 1988-1993

Abstract

OBJECTIVES We examined the hypothesis that mitral annulus calcification (MAC), aortic valve sclerosis (AVS) and aortic root calcification (ARC) are associated with coronary artery disease (CAD) in subjects age less than or equal to 65 years. BACKGROUND Mitral annulus calcification, AVS and ARC frequently coexist and arc associated with coronary risk factors and CAD in the elderly. METHODS We studied 338 subjects age less than or equal to 65 years who underwent evaluation of chest pain with myocardial perfusion single photon emission computed tomography (SPECT) and a two-dimensional transthoracic echocardiogram for other indications. The association of MAC, AVS and ARC with abnormal SPECT was evaluated by using chi-square analyses and logistic regression analyses. RESULTS Compared with no or one calcium deposit and no or one coronary risk factor other than diabetes, multiple (greater than or equal to2) calcium (or sclerosis) deposits with diabetes or multiple (greater than or equal to2) coronary risk factors were significantly associated with abnormal SPECT in women age less than or equal to 55 years old (odds ratio [OR], 20.00), in women age >55 years old (OR, 10,00) and in men age less than or equal to 55 years old (OR, 5.55). Multivariate analyses identified multiple calcium deposits as a significant predictor for an abnormal SPECT in women (p < 0.001), younger subjects age <less than or equal to>55 years (p < 0.05) and the total group of subjects (p < 0.01). CONCLUSIONS When coronary risk factors are also taken into consideration, the presence of multiple calcium deposits in the mitral annulus, aortic valve or aortic root appears to be a marker of CAD in men less than or equal to 55 years old and women. (J Am Coll Cardiol 2001;38:1988-93) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:10:08