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Titolo:
Adjunctive antipsychotic treatment of adolescents with bipolar psychosis
Autore:
Kafantaris, V; Coletti, DJ; Dicker, R; Padula, G; Kane, JM;
Indirizzi:
Hillside Hosp, Dept Psychiat, Glen Oaks, NY 11004 USA Hillside Hosp Glen Oaks NY USA 11004 pt Psychiat, Glen Oaks, NY 11004 USA
Titolo Testata:
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
fascicolo: 12, volume: 40, anno: 2001,
pagine: 1448 - 1456
SICI:
0890-8567(200112)40:12<1448:AATOAW>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LITHIUM TREATMENT; RATING-SCALE; ACUTE MANIA; HALOPERIDOL; DIVALPROEX; DISORDERS; PLACEBO; DYSKINESIA; DEPRESSION; DOSAGE;
Keywords:
bipolar; psychosis; treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kafantaris, V POB 38, Glen Oaks, NY 11004 USA POB 38 Glen Oaks NY USA 11004 B 38, Glen Oaks, NY 11004 USA
Citazione:
V. Kafantaris et al., "Adjunctive antipsychotic treatment of adolescents with bipolar psychosis", J AM A CHIL, 40(12), 2001, pp. 1448-1456

Abstract

Background: A combination of an antipsychotic medication and a mood stabilizer is often used for initial treatment of acute psychotic mania. However,the optimal duration of this adjunctive antipsychotic medication is unknown. Method; As part of a lithium efficacy study, acutely manic adolescents with psychotic features were given open combination treatment with lithium and an adjunctive antipsychotic medication. If the psychosis resolved, the antipsychotic medication dose was gradually tapered and discontinued after 4weeks of therapeutic lithium levels. The subject was then given a trial ofmaintenance lithium monotherapy for up to 4 weeks. Results: Significant improvement was seen in 64% of the sample with psychotic features after 4 weeks of combination treatment. However, few maintained their response after discontinuation of the antipsychotic medication. Successful discontinuation of antipsychotic medication in this sample was associated with first episode, shorter duration of psychosis, and the presence of thought disorder at baseline. Conclusions: Adjunctive antipsychotic medication needs to be maintained for longer than 4 weeks in the vast majority of adolescents with psychotic mania, even though the manic and psychotic symptoms have resolved andlithium treatment is maintained. Future studies to determine the optimal duration of adjunctive antipsychotic medication treatment are warranted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 10:06:52