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Titolo:
Circadian secretion of cortisol in bipolar disorder
Autore:
Cervantes, P; Gelber, S; Kin, FNKNY; Nair, VNP; Schwartz, G;
Indirizzi:
Montreal Gen Hosp, Affect Disorders Unit, Montreal, PQ H3G 1A4, Canada Montreal Gen Hosp Montreal PQ Canada H3G 1A4 Montreal, PQ H3G 1A4, Canada Montreal Gen Hosp, Dept Psychiat, Montreal, PQ H3G 1A4, Canada Montreal Gen Hosp Montreal PQ Canada H3G 1A4 Montreal, PQ H3G 1A4, Canada McGill Univ, Dept Psychiat, Montreal, PQ H3A 2T5, Canada McGill Univ Montreal PQ Canada H3A 2T5 hiat, Montreal, PQ H3A 2T5, Canada Douglas Hosp, Res Ctr, Verdun, PQ H4H 1R3, Canada Douglas Hosp Verdun PQ Canada H4H 1R3 Res Ctr, Verdun, PQ H4H 1R3, Canada
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
fascicolo: 5, volume: 26, anno: 2001,
pagine: 411 - 416
SICI:
1180-4882(200111)26:5<411:CSOCIB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS-DEPRESSION; MANIA; MELATONIN; SCALE;
Keywords:
affective symptoms; bipolar disorder; circadian rhythms; depression; hydrocortisone; laboratory techniques and procedures; psychiatric status rating scales;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Cervantes, P Montreal Gen Hosp, Affect Disorders Unit, 1650 Cedar Ave, Montreal, PQ H3G1A4, Canada Montreal Gen Hosp 1650 Cedar Ave Montreal PQ Canada H3G 1A4 a
Citazione:
P. Cervantes et al., "Circadian secretion of cortisol in bipolar disorder", J PSYCH NEU, 26(5), 2001, pp. 411-416

Abstract

Objective: To compare the 24-h cortisol secretion profiles of normal control subjects and patients with bipolar disorder who were in the depressive, manic and euthymic phases of the disorder. Participants: Eighteen patients,25-62 years of age, in depressed (n = 5), manic (n = 5) or euthymic (n = 8) phase of bipolar disorder recruited through a psychiatric outpatient clinic, and 5 control subjects, 24-41 years of age, recruited through advertisement or word of mouth. Outcome measures: Subjects were interviewed and symptom ratings were obtained using the Hamilton Depression Rating Scale, Beck Depression Inventory and Young Mania Scale. Blood collection began at 0800 and continued at hourly intervals for 24 h. Serum cortisol levels were assayed using a validated commercial radioimmunoassay kit. Results: An analysisof variance of the area under the cortisol 24-h time-concentration curve (AUC) revealed a significant difference between the control group and patient groups (F = 3.69, p = 0.03). The mean AUCs of the patients in the depressed (263.4 mug/dL) and hypomanic (262.2 mug/dL) phases were beyond the 95% confidence interval for the controls (120.9-253.3 mug/dL). There were no significant group differences in cosinor acrophase and no significant effects of sex, education, age of illness onset, duration of illness or duration ofmood state at time of testing on the cortisol measures. Pearson correlations between symptom rating scores and cortisol secretion variables were not significant. Conclusion: The increases in cortisol secretion in patients inboth the depressed and manic phases of bipolar disorder suggest that cortisol level is probably not a state marker in bipolar disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:32:37