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Titolo:
Animal models of schizophrenia: a critical review
Autore:
Marcotte, ER; Pearson, DM; Srivastava, LK;
Indirizzi:
Douglas Hosp, Res Ctr, Verdun, PQ H4H 1R3, Canada Douglas Hosp Verdun PQ Canada H4H 1R3 Res Ctr, Verdun, PQ H4H 1R3, Canada McGill Univ, Dept Psychiat, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Univ, Dept Psychiat, Montreal, PQ, Canada McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Neurol & Neurosurg, Montreal, PQ, Canada
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
fascicolo: 5, volume: 26, anno: 2001,
pagine: 395 - 410
SICI:
1180-4882(200111)26:5<395:AMOSAC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; IBOTENIC ACID LESIONS; NEONATAL HIPPOCAMPAL DAMAGE; NUCLEUS-ACCUMBENS DOPAMINE; CELL-ADHESION MOLECULE; INTRACEREBROVENTRICULAR KAINIC ACID; HALOPERIDOL-INDUCED CATALEPSY; INDUCED STEREOTYPIC BEHAVIORS; INDUCED LOCOMOTOR-ACTIVITY; 5-HT3 RECEPTOR ANTAGONIST;
Keywords:
brain; causality; developmental biology; dopamine; GABA; genetic predisposition to disease; genetics, biochemical; glutamic acid; disease models, animal; neural pathways; neuronal plasticity; pharmacology; psychopathology; schizophrenia; serotonin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
275
Recensione:
Indirizzi per estratti:
Indirizzo: Srivastava, LK Douglas Hosp, Res Ctr, 6875 LaSalle Blvd, Verdun, PQ H4H 1R3, Canada Douglas Hosp 6875 LaSalle Blvd Verdun PQ Canada H4H 1R3 ada
Citazione:
E.R. Marcotte et al., "Animal models of schizophrenia: a critical review", J PSYCH NEU, 26(5), 2001, pp. 395-410

Abstract

Current research into schizophrenia has remained highly fragmented, much like the clinical presentation of the disease itself. Differing theories as to the cause and progression of schizophrenia, as well as the heterogeneityof clinical symptoms, have made it difficult to develop a coherent framework suitable for animal modelling. However, a number of limited animal models have been developed to explore various causative theories and to test specific mechanistic hypotheses. Historically, these models have been based onthe manipulation of neurotransmitter systems believed to be involved in schizophrenia. In recent years, the emphasis has shifted to targeting relevant brain regions in an attempt to explore potential etiologic hypotheses. The specific animal models developed within these frameworks are described inthis review. Emphasis is placed on the critical evaluation of currently available models because these models help to shape the direction of future research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:11:08