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Titolo:
How do the atypical antipsychotics work?
Autore:
Ananth, J; Burgoyne, KS; Gadasalli, R; Aquino, S;
Indirizzi:
Univ Calif Los Angeles, Dept Psychiat, Torrance, CA 90509 USA Univ Calif Los Angeles Torrance CA USA 90509 hiat, Torrance, CA 90509 USA Harbor UCLA Med Ctr, Torrance, CA 90509 USA Harbor UCLA Med Ctr Torrance CA USA 90509 Med Ctr, Torrance, CA 90509 USA
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
fascicolo: 5, volume: 26, anno: 2001,
pagine: 385 - 394
SICI:
1180-4882(200111)26:5<385:HDTAAW>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; D-2 RECEPTOR OCCUPANCY; THALAMIC MEDIODORSAL NUCLEUS; MIDBRAIN DOPAMINE NEURONS; MEDIAL PREFRONTAL CORTEX; H-3 QUINPIROLE BINDING; IMMEDIATE-EARLY GENES; RAT STRIATAL NEURONS; MESSENGER-RNA LEVELS; NEUROLEPTIC DRUGS;
Keywords:
antipsychotic agents; brain; catalepsy; clozapine; disease models, animal; dopamine; gene expression regulation; genes, fos; haloperidol; midline thalamic nuclei; neostriatum; neurotensin; nucleus accumbens; prefrontal cortex; proto-oncogene proteins c-fos; receptors, dopamine; receptors, serotonin; schizophrenia; septal nuclei;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Ananth, J Univ Calif Los Angeles, Dept Psychiat, 1000 W Carson St,Bldg F-9, Torrance, CA 90509 USA Univ Calif Los Angeles 1000 W Carson St,Bldg F-9 Torrance CA USA 90509
Citazione:
J. Ananth et al., "How do the atypical antipsychotics work?", J PSYCH NEU, 26(5), 2001, pp. 385-394

Abstract

Understanding the action of atypical antipsychotics is useful in exploringthe pathophysiology of schizophrenia and in synthesizing drugs that improve various domains of psychopathology without unwanted side effects. In animal models, atypical antipsychotic drugs appear to have a preferential action in the limbic dopaminergic system. Regionally specific action has been studied by measuring the amount of Fos protein produced in a particular brainregion as a consequence of a drug's effects on the c-fos gene. Evidence suggests that the atypical and typical antipsychotic drug-induced increases in Fos levels in the nucleus accumbens are related to improvements in positive symptoms, whereas Fos increases in the prefrontal cortex, with the atypical antipsychotics only, correlate with negative symptom improvement. The extrapyramidal effects seen with typical antipsychotics are thought to be related to Fos increases in the striatonigral pathway. However, studies of Fos levels in specific brain regions reveal only the site of action, not the mode of action. The finding that atypicality is related to surmountable D-2dopamine receptor blocking provides another venue to define and explore atypical antipsychotic drug action.

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Documento generato il 27/01/20 alle ore 01:23:48