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Titolo:
Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration
Autore:
Nanji, AA; Jokelainen, K; Lau, GKK; Rahemtulla, A; Tipoe, GL; Polavarapu, R; Lalani, EN;
Indirizzi:
Queen Mary Hosp, Clin Biochem Unit, Hong Kong, Hong Kong, Peoples R China Queen Mary Hosp Hong Kong Hong Kong Peoples R China ong, Peoples R China Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Hong Kong, Ctr Study Liver Dis, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Helsinki Hosp, Alcohol Dis Res Unit, Helsinki, Finland Univ Helsinki Hosp Helsinki Finland hol Dis Res Unit, Helsinki, Finland Univ Hong Kong, Div Gastroenterol & Hepatol, Hong Kong, Hong Kong, PeoplesR China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, PeoplesR China Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA Univ Hong Kong, Dept Anat, Hong Kong, Hong Kong, Peoples R China Univ HongKong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Emory Univ, Sch Med, DNA Sequencing Core Facil, Atlanta, GA USA Emory Univ Atlanta GA USA ed, DNA Sequencing Core Facil, Atlanta, GA USA Emory Univ, Sch Med, Dept Biochem, Atlanta, GA USA Emory Univ Atlanta GA USA y Univ, Sch Med, Dept Biochem, Atlanta, GA USA Hammersmith Hosp, Dept Histopathol, London W12 0HS, England Hammersmith Hosp London England W12 0HS opathol, London W12 0HS, England Imperial Coll Med, London, England Imperial Coll Med London EnglandImperial Coll Med, London, England
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 3, volume: 299, anno: 2001,
pagine: 832 - 839
SICI:
0022-3565(200112)299:3<832:AREIAF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; DISEASE; RAT; INJURY; NECROSIS; SEVERITY; CYTOCHROME-P-450; FIBROSIS; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Nanji, AA Queen Mary Hosp, Clin Biochem Unit, LG 136,Block K,102 Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China Queen Mary Hosp LG 136,Block K,102 Pokfulam Rd Hong Kong Hong Kong Peoples R China
Citazione:
A.A. Nanji et al., "Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration", J PHARM EXP, 299(3), 2001, pp. 832-839

Abstract

We investigated the potential of arginine to reverse pathological changes in alcohol-induced liver injury. Four groups (six rats/group) of male Wistar rats were fed a fish oil-ethanol diet for 6 (group 2) or 8 (group 1) weeks. Rats in group 3 were fed fish oil-ethanol for 6 weeks, after which they were administered arginine with fish oil-ethanol for an additional 2 weeks. Rats in group 4 were fed fish oil-dextrose for 8 weeks. Liver samples wereanalyzed for histopathology, lipid peroxidation, cytochrome P4502E1 activity, nuclear factor-kappaB, and levels of messenger RNA for tumor necrosis factor-alpha, cyclooxygenase-2, and inducible nitric oxide synthase. Concentrations of endotoxin were measured in plasma. The most severe inflammation and fibrosis was detected in groups 1 and 2, as were the highest levels of endotoxin, lipid peroxidation, cytochrome P450 2E1 activity, activation of nuclear factor-kappaB, and mRNA levels for tumor necrosis factor-alpha, cyclooxygenase-2, and inducible nitric oxide synthase. Plasma nitric oxide wasalso increased as was nitrotyrosine in liver. After arginine was administered, there was marked improvement in the pathological changes accompanied by decreased levels of endotoxin, lipid peroxidation, activation of nuclear factor-kappaB, tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide, and nitrotyrosine staining. The therapeutic effects of arginine are probably secondary to increased levels of nitric oxide but other effects of arginine cannot be excluded.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:56:32