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Titolo:
Multiple behavioral effects of cocaine-and amphetamine-regulated transcript (CART) peptides in mice: CART 42-89 and CART 49-89 differ in potency and activity
Autore:
Bannon, AW; Seda, J; Carmouche, M; Francis, JM; Jarosinski, MA; Douglass, J;
Indirizzi:
Amgen Inc, Neurosci, Thousand Oaks, CA 91320 USA Amgen Inc Thousand Oaks CA USA 91320 eurosci, Thousand Oaks, CA 91320 USA Amgen Boulder inc, Peptide Chem, Longmont, CO USA Amgen Boulder inc Longmont CO USA er inc, Peptide Chem, Longmont, CO USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 3, volume: 299, anno: 2001,
pagine: 1021 - 1026
SICI:
0022-3565(200112)299:3<1021:MBEOCA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPULSE INHIBITION; NUCLEUS-ACCUMBENS; ACOUSTIC STARTLE; RAT-BRAIN; DOPAMINE; LESIONS; LEPTIN; REFLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Bannon, AW Amgen Inc, Neurosci, 1 Amgen Ctr Dr,M-S 29-1-A, Thousand Oaks, CA 91320 USA Amgen Inc 1 Amgen Ctr Dr,M-S 29-1-A Thousand Oaks CA USA 91320
Citazione:
A.W. Bannon et al., "Multiple behavioral effects of cocaine-and amphetamine-regulated transcript (CART) peptides in mice: CART 42-89 and CART 49-89 differ in potency and activity", J PHARM EXP, 299(3), 2001, pp. 1021-1026

Abstract

Cocaine- and amphetamine-regulated transcript (CART) encodes a neuropeptide precursor protein that is highly abundant in cells of the hypothalamus. To date, the major research focus into the function of CART peptides has been feeding behavior. However, CART mRNA is found in other areas of the brainas well as some peripheral tissues, suggesting possible broader functions of this peptide. In this study, we investigated the effects of two CART peptides, CART 42-89 and CART 49-89, in several behavioral assays. Peptides were administered by i.c.v. route of administration. Both CART 42-89 and CART49-89 inhibited food intake with the minimally effective dose of CART 42-89 (0.5 mug) being 5-fold greater than that of CART 49-89 (0.1 mug). Both peptides also produced significant antinociceptive effects in the hot-plate assay with similar potency differences. CART 42-89 significantly inhibited the acoustic startle response (ASR) of pulse alone trials at doses of 0.1 and 0.5 mug. In contrast, CART 49-89 did not affect ASR of pulse alone trialsat doses of 0.05 and 0.1 (mug). For prepulse inhibition (PPI) trials, in general, both peptides appeared to enhance the magnitude of PPI and CART 42-89 was less potent than CART 49-89. Overall, these data suggest CART peptides may have multiple roles in central nervous system function and there maybe biological differences between two processed forms of CART peptide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:02:28