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Titolo:
Extractive-spectrophotometric determination of some phenothiazines with dipicrylamine and picric acid
Autore:
Regulska, E; Tarasiewicz, M; Puzanowska-Tarasiewicz, H;
Indirizzi:
Bialystok Tech Univ, Dept Chem, PL-15435 Bialystok, Poland Bialystok Tech Univ Bialystok Poland PL-15435 PL-15435 Bialystok, Poland Univ Bialystok, Inst Chem, Bialystok, Poland Univ Bialystok Bialystok Poland Bialystok, Inst Chem, Bialystok, Poland
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 1-2, volume: 27, anno: 2002,
pagine: 335 - 340
SICI:
0731-7085(20020101)27:1-2<335:EDOSPW>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; 10-DISUBSTITUTED PHENOTHIAZINES; DERIVATIVES; DRUGS;
Keywords:
spectrophotometric; promethazine; perphenazine; pharmaceutical preparations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Regulska, E Bialystok Tech Univ, Dept Chem, Zamenhofa 29, PL-15435 Bialystok, Poland Bialystok Tech Univ Zamenhofa 29 Bialystok Poland PL-15435 nd
Citazione:
E. Regulska et al., "Extractive-spectrophotometric determination of some phenothiazines with dipicrylamine and picric acid", J PHARM B, 27(1-2), 2002, pp. 335-340

Abstract

Dipicrylamine and picric acid have been tested as reagents for the determination of promethazine and perphenazine. They react in neutral media with these drugs forming the coloured compounds. The compounds are sparingly soluble in water and quantitatively extracted into organic solvents. The extracts are intensely coloured and very stable. These properties have been exploited for the extractive spectrophotometric determination of promethazine and perphenazine in pure solutions and pharmaceuticals. Linear calibration graphs were obtained in the concentration range 4-40, 3-30 mug ml(-1) of promethazine and 4-80, 8-60 mug ml(-1) of perphenazine for picric acid and dipicrylamine, respectively. The relative standard deviation (RSD) is less than0.8%. (C) 2002 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/06/20 alle ore 06:39:12