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Titolo:
Flow injection analysis with multiple on-line spectroscopic analysis (UV, IR, H-1-NMR and MS)
Autore:
Lenz, E; Taylor, S; Collins, C; Wilson, ID; Louden, D; Handley, A;
Indirizzi:
AstraZeneca Pharmaceut, Drug Metab & Pharmacokinet Dept, Macclesfield SK104TG, Cheshire, England AstraZeneca Pharmaceut Macclesfield Cheshire England SK10 4TG re, England LGC, Runcorn WA7 4QD, Cheshire, England LGC Runcorn Cheshire England WA7 4QD , Runcorn WA7 4QD, Cheshire, England
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 1-2, volume: 27, anno: 2002,
pagine: 191 - 200
SICI:
0731-7085(20020101)27:1-2<191:FIAWMO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; PERFORMANCE LIQUID-CHROMATOGRAPHY; HPLC-NMR-MS; SIZE-EXCLUSION CHROMATOGRAPHY; FLIGHT MASS-SPECTROMETRY; ONLINE COLLECTION; DIODE-ARRAY; HUMAN URINE; IDENTIFICATION; METABOLITES;
Keywords:
flow injection analysis; multiple hyphenation; spectroscopic characterisation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Wilson, ID AstraZeneca Pharmaceut, Drug Metab & Pharmacokinet Dept, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England AstraZeneca Pharmaceut Alderley Pk Macclesfield Cheshire England SK10 4TG
Citazione:
E. Lenz et al., "Flow injection analysis with multiple on-line spectroscopic analysis (UV, IR, H-1-NMR and MS)", J PHARM B, 27(1-2), 2002, pp. 191-200

Abstract

Studies on the capabilities of flow injection analysis (FIA) combined withon-line characterisation of model compounds via a combination of diode array UV, H-1-NMR, FT-IR spectroscopy and mass spectrometry are described. Using this combination of spectrometers enabled the on-flow collection of UV, H-1-NMR, IR and MS for a range of model compounds. Samples were introduced into the system as solutions in deuterium oxide in concentrations ranging from 1.4 to 8.4 mg ml(-1). A sample volume of 100 mul was used for FIA at a flow rate of 1 ml min(-1). From these studies a practical working quantity of ca. 140 mug/sample of analyte was determined which provided characteristic spectra. (C) 2002 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:17:30