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Titolo:
A new HPLC method to determine Donepezil hydrochloride in tablets
Autore:
Pappa, H; Farru, R; Vilanova, PO; Palacios, M; Pizzorno, MT;
Indirizzi:
Univ Buenos Aires, Fac Farm & Bioquim, Catedra Control Calidad Medicamentos, RA-1113 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1113 Aires, DF, Argentina
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 1-2, volume: 27, anno: 2002,
pagine: 177 - 182
SICI:
0731-7085(20020101)27:1-2<177:ANHMTD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY; ENANTIOMERS; PLASMA; E2020;
Keywords:
Donepezil hydrochloride; assay; HPLC; validation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Pizzorno, MT Univ Buenos Aires, Fac Farm & Bioquim, Catedra Control Calidad Medicamentos, Junin 956, RA-1113 Buenos Aires, DF, Argentina Univ Buenos Aires Junin 956 Buenos Aires DF Argentina RA-1113
Citazione:
H. Pappa et al., "A new HPLC method to determine Donepezil hydrochloride in tablets", J PHARM B, 27(1-2), 2002, pp. 177-182

Abstract

A HPLC stability-indicating assay for Donepezil hydrochloride in tablets was developed and validated. Donepezil hydrochloride is a reversible inhibitor of acetylcholinesterase, indicated for the treatment of mild to moderatedementia of the Alzheimer's type. The HPLC method was performed with a reversed phase C18 column, detection at 268 ran and a mixture of methanol, phosphate buffer 0.02 M and triethylamine (50:50:0.5) as mobile phase. Typicalretention time for Donepezil was 9 min. The method was statistically validated for linearity, accuracy, precision and selectivity following ICH recommendations. Due to its simplicity and accuracy, the method can be used for routine quality control analysis. (C) 2002 Elsevier Science B.V. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 03:57:02