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Titolo:
Simultaneous enantioseparation of cis-diltiazem hydrochloride and its metabolite cis-desacetyldiltiazem using high-performance liquid chromatography and capillary electrophoresis
Autore:
Chankvetadze, B; Kartozia, I; Blaschke, G;
Indirizzi:
Univ Munster, Inst Pharmaceut Chem, D-48149 Munster, Germany Univ MunsterMunster Germany D-48149 ceut Chem, D-48149 Munster, Germany
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 1-2, volume: 27, anno: 2002,
pagine: 161 - 166
SICI:
0731-7085(20020101)27:1-2<161:SEOCHA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLULOSE TRIS(3,5-DICHLOROPHENYLCARBAMATE); CHIRAL SEPARATION; OPTICAL ISOMERS; HUMAN PLASMA; BULK DRUG; POLYSACCHARIDES; RESOLUTION; PHASE; RECOGNITION; STABILITY;
Keywords:
capillary electrophoresis; enantioseparation; HPLC; chiral selector; cyclodextrin; cis-diltiazem hydrochloride; cis-desacetyldiltiazem;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Blaschke, G Univ Munster, Inst Pharmaceut Chem, Hittorfstr 58-62, D-48149 Munster, Germany Univ Munster Hittorfstr 58-62 Munster Germany D-48149 Germany
Citazione:
B. Chankvetadze et al., "Simultaneous enantioseparation of cis-diltiazem hydrochloride and its metabolite cis-desacetyldiltiazem using high-performance liquid chromatography and capillary electrophoresis", J PHARM B, 27(1-2), 2002, pp. 161-166

Abstract

Two alternative methods were developed using high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) for a simultaneous enantioselective determination of Ca2+ blocking chiral drug cis-diltiazem hydrochloride (DLT) and its degradation product and metabolite cis-desacetyldiltiazem (Desac-DLT). The methods were compared from the viewpoint of analytical performance. The identification of HPLC peaks were performed using off-line electrospray ionization mass spectrometry. In addition, CE method was evaluated for quantitative determination of minor enantiomeric impurities inpharmacologically active (+)-cis-DLT. (C) 2002 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:33:21