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Titolo:
Determination of verapamil in pharmaceutical formulations using atomic emission spectrometry
Autore:
Khalil, S; Kelzieh, A;
Indirizzi:
Cairo Univ, Fac Sci, Dept Chem, Fayoum Branch, Al Fayyum 63514, Egypt Cairo Univ Al Fayyum Egypt 63514 , Fayoum Branch, Al Fayyum 63514, Egypt Tichreen Univ, Fac Sci, Dept Chem, Latakia 11491, Riyadh, Syria Tichreen Univ Latakia Riyadh Syria 11491 em, Latakia 11491, Riyadh, Syria
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 1-2, volume: 27, anno: 2002,
pagine: 123 - 131
SICI:
0731-7085(20020101)27:1-2<123:DOVIPF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTASSIUM FERRICYANIDE; SODIUM COBALTINITRITE; AMMONIUM REINECKATE; HUMAN-PLASMA; ASSAY; DRUGS; PHASE; HYDROCHLORIDE; NORVERAPAMIL; PROPRANOLOL;
Keywords:
atomic emission spectrometry; verapamil; ion-associate complexes; pharmaceutical analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Khalil, S Teachers Coll, Dept Chem, POB 4341, Riyadh 11491, Saudi Arabia Teachers Coll POB 4341 Riyadh Saudi Arabia 11491 , Saudi Arabia
Citazione:
S. Khalil e A. Kelzieh, "Determination of verapamil in pharmaceutical formulations using atomic emission spectrometry", J PHARM B, 27(1-2), 2002, pp. 123-131

Abstract

Ion-associate complexes of verapamil hydrochloride (VpCl) with (Cd(II), Co(II), Mn(II), and Zn(II)) thiocyanates, potassium ferricyanide, and ammonium reineckate are precipitated. The solubility of the solid complexes at therecommended optimum conditions of pH and ionic strength values have been studied. Saturated solutions of each ion associate at different temperaturesunder the optimum precipitation conditions were prepared and the metal ioncontents in the supernatant were determined. The solubility products were thus calculated at different temperatures and the thermodynamic parameters DeltaH, DeltaG, and DeltaS were calculated. A new accurate and precise method based on direct coupled plasma atomic emission spectrometry for the determination of VpCl (1.96-62.86 mug ml(-1)) in pure solutions and pharmaceutical preparations is given. (C) 2002 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:06:57