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Titolo:
Kinetic spectrophotometric determination of nizatidine and ranitidine in pharmaceutical preparations
Autore:
Hassan, EM; Belal, F;
Indirizzi:
King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia King Saud Univ Riyadh Saudi Arabia 11451 hem, Riyadh 11451, Saudi Arabia
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 1-2, volume: 27, anno: 2002,
pagine: 31 - 38
SICI:
0731-7085(20020101)27:1-2<31:KSDONA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; POLAROGRAPHIC-DETERMINATION; HUMAN PLASMA; FORMULATIONS; HYDROCHLORIDE; FAMOTIDINE; BEHAVIOR;
Keywords:
nizatidine; ranitidine; kinetic spectrophotometric method;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Belal, F King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, POB 2457, Riyadh 11451, Saudi Arabia King Saud Univ POB 2457 Riyadh Saudi Arabia 11451 , Saudi Arabia
Citazione:
E.M. Hassan e F. Belal, "Kinetic spectrophotometric determination of nizatidine and ranitidine in pharmaceutical preparations", J PHARM B, 27(1-2), 2002, pp. 31-38

Abstract

A new simple and sensitive kinetic spectrophotometric method is described for analysis of nizatidine (I) and ranitidine (II). The method involves thereaction of the drugs with alkaline potassium permanganate, whereby a green color peaking at 610 nm is produced. The reaction is monitored spectrophotometrically by measuring the rate of change of absorbance of the resultingmanganate species at 610 nm. Calibration graphs are linear over the concentration range 0.8-4.0 mug/ml and the precision (% RSD 1.80, 1.53 for I and II, respectively) is quite acceptable. The method is satisfactorily appliedfor direct analysis of pharmaceutical preparations containing I and II. A proposal of the reaction pathway is postulated. (C) 2002 Elsevier Science B. V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 10:04:17