Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dual-mode gradient HPLC procedure for the simultaneous determination of chloroquine and proguanil
Autore:
Paci, A; Caire-Maurisier, AM; Rieutord, A; Brion, F; Clair, P;
Indirizzi:
Lab Controle Pharm Cent Armees, Orleans, France Lab Controle Pharm Cent Armees Orleans France t Armees, Orleans, France Hop Robert Debre, Serv Pharm, Lab Toxicopharmacol, F-75019 Paris, France Hop Robert Debre Paris France F-75019 copharmacol, F-75019 Paris, France
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 1-2, volume: 27, anno: 2002,
pagine: 1 - 7
SICI:
0731-7085(20020101)27:1-2<1:DGHPFT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN-PLASMA; METABOLITES; URINE;
Keywords:
chloroquine sulfate; proguanil hydrochloride; HPLC-UV; quality-control; validation; elution and flow-rate gradient;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Paci, A Lab Controle Pharm Cent Armees, Orleans, France Lab Controle PharmCent Armees Orleans France , Orleans, France
Citazione:
A. Paci et al., "Dual-mode gradient HPLC procedure for the simultaneous determination of chloroquine and proguanil", J PHARM B, 27(1-2), 2002, pp. 1-7

Abstract

In order to assay the antipaludic capsule of the Service de Sante des Armees (SSA), that contains two antimalarial drugs, i.e. chloroquine sulfate (CQS, cp1) and proguanil hydrochloride (PGH, cp5), a HPLC procedure was developed. A reversed-phase ion-pair high-performance liquid chromatography (HPLC) method with an ultraviolet detection at 254 nm was set up and validated. Elution system includes programming of both organic concentration and flow-rate known as 'dual-mode gradient'. This method allows the simultaneous determination of both active compounds and separation of four process relatedsubstances. The method is simple, rapid, selective and accurate, and the precision is good with an inter- and intra-assay of < 2%. The sensitivity isparticularly suitable for pharmaceutical quality control. (C) 2002 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:01:52