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Titolo:
Associations between serum antibody levels to periodontal pathogens and early-onset periodontitis
Autore:
Albandar, JM; DeNardin, AM; Adesanya, MR; Diehl, SR; Winn, DM;
Indirizzi:
Temple Univ, Sch Dent, Dept Periodontol, Philadelphia, PA 19140 USA TempleUniv Philadelphia PA USA 19140 odontol, Philadelphia, PA 19140 USA SUNY Coll Buffalo, Dept Oral Biol, Buffalo, NY USA SUNY Coll Buffalo Buffalo NY USA uffalo, Dept Oral Biol, Buffalo, NY USA NIDCR, Craniofacial Epidemiol & Genet Branch, Bethesda, MD USA NIDCR Bethesda MD USA ofacial Epidemiol & Genet Branch, Bethesda, MD USA
Titolo Testata:
JOURNAL OF PERIODONTOLOGY
fascicolo: 11, volume: 72, anno: 2001,
pagine: 1463 - 1469
SICI:
0022-3492(200111)72:11<1463:ABSALT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
G SUBCLASS CONCENTRATIONS; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; PORPHYROMONAS-GINGIVALIS; YOUNG-ADULTS; JUVENILE PERIODONTITIS; IMMUNOGLOBULIN ALLOTYPES; DISEASE; RESPONSES; SMOKING; RACE;
Keywords:
periodontal diseases/pathogenesis; periodontal diseases/immunology; antibodies; Actinobacillus actinomycetemcomitans; Porphyromonas gingivalis; Prevotella intermedia; Campylobacter rectus; Eikenella corrodens; Fusobacterium nucleatum; follow-up studies; blacks; periodontitis, early-onset/etiology; periodontitis, early-onset/pathogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Albandar, JM Temple Univ, Sch Dent, Dept Periodontol, 3223 N Broad St, Philadelphia, PA19140 USA Temple Univ 3223 N Broad St Philadelphia PA USA 19140 140 USA
Citazione:
J.M. Albandar et al., "Associations between serum antibody levels to periodontal pathogens and early-onset periodontitis", J PERIODONT, 72(11), 2001, pp. 1463-1469

Abstract

Background: The role of antibodies to periodontal microorganisms in the development of periodontal tissue destruction is still unclear. The aim of this study was to investigate the association between serum levels of IgG, IgA, and IgM antibodies to 6 periodontal microorganisms and clinical subtypesof varying severity of early-onset periodontitis (EOP) in young African American adults. Methods: The study group consisted of 159 African Americans aged 19 to 25 years (mean 22 years) and included 97 cases with EOP and 62 controls with no clinical signs of EOP. These subjects were selected from a nationally representative sample of adolescents who received an oral examination as part of the National Survey of Oral Health of United States Children in 1986-1987. The group was examined clinically a second time 6 years later and blood samples were collected. Serum levels of IgG, IgA, and IgM reactive to Actinobacillas actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Campylobacter rectus, Eikenella corrodens, and Fusobacterium nucleatum were assessed. Results: Serum levels of IgG and IgA antibody reactive to P gingivalis andA. actinomycetemcomitans and IgA antibody to P intermedia were significantly higher in generalized EOP cases compared to healthy controls. IgM antibody levels did not show any significant associations with EOP for any of the6 bacterial species tested. There were no significant differences in antibody levels between controls and the 13 subjects in our study who were classified with localized EOP. Conclusions: The findings suggest that antibodies to P gingivalis, P intermedia, and A. actinomycetemcomitans may play a significant role in the pathogenesis of EOP. Substantial longitudinal studies that monitor antibody levels and avidity prior to disease onset, during progression, and following clinical intervention will be necessary to fully understand the role of thiscomponent of the immune response in protection versus tissue destruction and the potential use in EOP risk assessment and disease management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 03:10:03