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Titolo:
FDOPA metabolism in the adult porcine brain: influence of tracer circulation time and VOI selection on estimates of striatal DOPA decarboxylation
Autore:
Danielsen, EH; Smith, DF; Andersen, F; Gee, AD; Bender, D; Hansen, SB; Hermansen, F; Ostergaard, L; Cumming, P; Gjedde, A;
Indirizzi:
Aarhus Univ Hosp, PET Ctr, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Aarhus Denmark C sp, PET Ctr, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp, Dept Neuroradiol, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 oradiol, DK-8000 Aarhus, Denmark Univ Aarhus, Hosp Psychiat, Dept Biol Psychiat, DK-8240 Risskov, Denmark Univ Aarhus Risskov Denmark DK-8240 l Psychiat, DK-8240 Risskov, Denmark Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada Montreal Neurol Inst Montreal PQ Canada maging Ctr, Montreal, PQ, Canada
Titolo Testata:
JOURNAL OF NEUROSCIENCE METHODS
fascicolo: 2, volume: 111, anno: 2001,
pagine: 157 - 168
SICI:
0165-0270(20011030)111:2<157:FMITAP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; CATECHOL-O-METHYLTRANSFERASE; AMINO-ACID DECARBOXYLASE; LIVING HUMAN BRAIN; PARKINSONS-DISEASE; IN-VIVO; MONKEY BRAIN; 6-FLUORO-L-DOPA; PET; KINETICS;
Keywords:
6-[F-18]fluoro-L-3,4-dihydroxyphenylalanine; FDOPA; PET; neuroimaging; swine/pigs/porcine; minipig; striatum; partial volume;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Danielsen, EH Aarhus Univ Hosp, PET Ctr, Norrebrogade 44, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Norrebrogade 44 Aarhus Denmark C , Denmark
Citazione:
E.H. Danielsen et al., "FDOPA metabolism in the adult porcine brain: influence of tracer circulation time and VOI selection on estimates of striatal DOPA decarboxylation", J NEUROSC M, 111(2), 2001, pp. 157-168

Abstract

Different methodologies for PET data analysis influence the magnitude of estimates of blood-brain transfer coefficients and rate constants for the metabolism of FDOPA in living striatum. We now test the effects on several kinetic parameters of automatic procedures for volume of interest (VOI) selection. We also tested the sensitivity of the estimates to dynamic frame sequence duration, and produced a standard method for minimizing the variationsin physiological estimates for FDOPA kinetics in minipig brain. We used minipigs because our previous work has shown them to provide an appropriate animal model for study normal and pathological cerebral DOPA metabolism using PET. Time-activity curves in striatum of adult minipigs were acquired in VOIs defined manually on MR-images, or alternatively on the basis of the radioactivity concentration based on the most radioactive voxel in the last scan frame. For all frame sequences, the relative decarboxylase activity (k(3)(D)) declined significantly (P < 0.006) as the VOI threshold declined from 95 to 70% of the most radioactive voxel. Irrespective of VOI size, the magnitude of k(3)(D) declined significantly (P < 0.001) from 0.074 +/- 0.008 to 0.045 +/- 0.005 per min (mean +/- S.E.M.) as total sequence length increased from 60 to 120 min circulation. The method of VOI selection had no significant effect on the striatum decarboxylation index of FDOPA calculated relative to the radioactivity in cerebellum (k(3)(S)). (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:07:48