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Titolo:
Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo
Autore:
Kelly, S; Chapman, V;
Indirizzi:
Univ Nottingham, Sch Med, Queens Med Ctr, Sch Biomed Sci, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH , Nottingham NG7 2UH, England
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 6, volume: 86, anno: 2001,
pagine: 3061 - 3064
SICI:
0022-3077(200112)86:6<3061:SCCRAI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL HORN; CALCIUM CHANNELS; N-TYPE; RAT; NEURONS; CORD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Chapman, V Univ Nottingham, Sch Med, Queens Med Ctr, Sch Biomed Sci, E Floor, Nottingham NG7 2UH, England Univ Nottingham E Floor Nottingham EnglandNG7 2UH UH, England
Citazione:
S. Kelly e V. Chapman, "Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo", J NEUROPHYS, 86(6), 2001, pp. 3061-3064

Abstract

Cannabinoid(1) (CB1) receptors are located at CNS sites, including the spinal cord, involved in somatosensory processing. Analgesia is one of the tetrad of behaviors associated with cannabinoid agonists. Here, effects of a potent cannabinoid CB1 receptor agonist arachidonyl-2-chloroethylamide (ACEA) on evoked responses of dorsal horn neurons in anesthetized rats were investigated. Extracellular recordings of convergent dorsal horn neurons were made in halothane anesthetized Sprague-Dawley rats (n=16). Effects of spinalapplication of ACEA on electrically evoked responses of dorsal horn neurons were studied. Mean maximal effects of 0.5, 5, 50, and 500 ng/50 mul ACEA on the C-fiber-mediated postdischarge response were 79 +/-6, 62 +/- 10, and54 +/-7% (P<0.01), 45<plus/minus>6% (P<0.01), of control, respectively. ACEA (500 ng/50 <mu>l) also reduced the C-fiber-evoked nonpotentiated responses of neurons (59 +/-9% of control, P<0.05) and A<delta>-fiber-evoked responses of neurons (68 +/- 10% of control, P<0.01). Minor effects of ACEA on A<beta>-fiber-evoked responses were observed. Spinal preadministration of the selective CB1 receptor antagonist SR141716A (0.01 mug/50 mul) significantly reduced effects of ACEA (500 ng/50 mul) on postdischarge responses of dorsal horn neurons. This study demonstrates that spinal CB1 receptors modulate the transmission of C- and A delta -fiber-evoked responses in anesthetized rats; this may reflect pre- and/or postsynaptic effects of cannabinoids on nociceptive transmission. CB1 receptors inhibit synaptic release of glutamate in rat dorsolateral striatum, a similar mechanism of action may underlie the effects of ACEA on noxious evoked responses of spinal neurons reported here.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:37:27