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Titolo:
Magnetisation transfer ratio analysis of normal appearing white matter in patients with familial and sporadic multiple sclerosis
Autore:
Siger-Zajdel, M; Selmaj, K;
Indirizzi:
Med Acad Lodz, Dept Neurol, Lodz, Poland Med Acad Lodz Lodz PolandMed Acad Lodz, Dept Neurol, Lodz, Poland
Titolo Testata:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
fascicolo: 6, volume: 71, anno: 2001,
pagine: 752 - 756
SICI:
0022-3050(200112)71:6<752:MTRAON>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIZATION TRANSFER CONTRAST; RECEPTOR ANTAGONIST GENES; MRI; MS; LESIONS; DISABILITY; GENETICS; SIBLINGS; TISSUE; ASSOCIATION;
Keywords:
familial multiple sclerosis; magnetic resonance imaging; magnetisation transfer ratio;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Selmaj, K Med Acad Lodz, Dept Neurol, 22 Kopcinskiego St, Lodz, Poland MedAcad Lodz 22 Kopcinskiego St Lodz Poland St, Lodz, Poland
Citazione:
M. Siger-Zajdel e K. Selmaj, "Magnetisation transfer ratio analysis of normal appearing white matter in patients with familial and sporadic multiple sclerosis", J NE NE PSY, 71(6), 2001, pp. 752-756

Abstract

Objectives-To assess differences in magnetisation transfer ratio (MTR) analysis of normal appearing white matter (NAWM) in patients with familial multiple sclerosis (MS) and those with sporadic MS. Methods-10 patients with familial MS, 10 patients with sporadic MS, and 10healthy subjects were included in the study. Groups were matched accordingto the sex, age, disease duration, type of disease, EDSS, and MRI T1 and T2 lesion load. Magnetisation transfer imaging (MTI) with and without saturation pulse were performed. On the MTR map 16 different regions of interest of normal appearing white matter were analyzed. Results-The mean MTR value of normal appearing white matter was significantly lower both in familial patients and those with sporadic MS compared with healthy subjects (33.8% v 46.4%; 38.6% v 46.4% respectively, p < 0.05). Additionally, patients with familial MS showed significantly lower mean MTR value than patients with sporadic MS (33.8% v 38.6%, p <0.05). There was also significant regional varation of MTR values between these two groups of patients. Conclusions-Lower and more widespread MTR abnormalities in patients with familial MS might indicate differences in the extent and nature of white matter pathology between familial and sporadic MS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:37:15