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Titolo:
Salsolinol. is a putative endogenous neuro-intermediate lobe prolactin-releasing factor
Autore:
Toth, BE; Homicsko, K; Radnai, B; Maruyama, W; DeMaria, JE; Vecsemyes, M; Fekete, MIK; Fulop, F; Naoi, M; Freeman, ME; Nagy, GM;
Indirizzi:
Semmelweis Univ Med, Dept Human Morphol & Dev Biol, Neuroendocrine Res Lab, H-1094 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1094 ab, H-1094 Budapest, Hungary Natl Inst Longev Sci, Dept Basic Gerontol, Aichi, Japan Natl Inst Longev Sci Aichi Japan Sci, Dept Basic Gerontol, Aichi, Japan Univ Penn, Med Ctr, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA UnivPenn Philadelphia PA USA 19104 & Lab Med, Philadelphia, PA 19104 USA Florida State Univ, Dept Biol Sci, Program Neurosci, Tallahassee, FL 32306USA Florida State Univ Tallahassee FL USA 32306 sci, Tallahassee, FL 32306USA Med Sch Debrecen, Dept Biopharm & Pharmacol, Debrecen, Hungary Med Sch Debrecen Debrecen Hungary opharm & Pharmacol, Debrecen, Hungary Hungarian Acad Sci, Inst Expt Med, Budapest, Hungary Hungarian Acad Sci Budapest Hungary i, Inst Expt Med, Budapest, Hungary Univ Szeged, Fac Pharm, Inst Pharmaceut Chem, Szeged, Hungary Univ SzegedSzeged Hungary Pharm, Inst Pharmaceut Chem, Szeged, Hungary Nagoya Inst Technol, Dept Biosci, Showa Ku, Nagoya, Aichi 466, Japan Nagoya Inst Technol Nagoya Aichi Japan 466 a Ku, Nagoya, Aichi 466, Japan
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 12, volume: 13, anno: 2001,
pagine: 1042 - 1050
SICI:
0953-8194(200112)13:12<1042:SIAPEN>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTERIOR PITUITARY CONTAINS; DOPAMINERGIC NEUROTOXIN; CEREBROSPINAL-FLUID; RAT; SECRETION; INVIVO; ALKALOIDS; INVITRO; PLASMA; CELLS;
Keywords:
neuro-intermediate lobe; salsolinol; prolactin-releasing activity; suckling stimulus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Nagy, GM Semmelweis Univ Med, Dept Human Morphol & Dev Biol, Neuroendocrine Res Lab, Tuzolto 58, H-1094 Budapest, Hungary Semmelweis Univ Med Tuzolto58 Budapest Hungary H-1094 , Hungary
Citazione:
B.E. Toth et al., "Salsolinol. is a putative endogenous neuro-intermediate lobe prolactin-releasing factor", J NEUROENDO, 13(12), 2001, pp. 1042-1050

Abstract

The isolation and identification of a prolactin-releasing factor (PRF) from the neuro-intermediate lobe of the pituitary gland has been pursued for over a decade. Using high-pressure liquid chromatography with electrochemical detection (HPLC-ECD) and gas chromatography/mass spectrometry (GUMS) (R)-salsolinol (SAL) (a dopamine-related stereo-specific tetrahydroisoquinoline) was found to be present in neuro-intermediate lobe as well as median eminence extracts of male, intact-, and ovariectomized female rats. Moreover, analysis of SAL concentrations in neuro-intermediate lobe revealed parallel increases with plasma prolactin in lactating rats exposed to a brief (10 min) suckling stimulus following 4-h separation. SAL appears to be a selective and potent stimulator of prolactin secretion in vivo and it was without effect on the secretion of, other pituitary hormones. We have also found that SAL can elevate prolactin release, although to a lesser extent, in pituitary cell cultures as well as in hypophysectomized rats bearing anterior lobe transplants under the kidney capsule. Lack of interference of SAL with [H-3]-spiperone binding to AP homogenates indicates that SAL does not act at the dopamine D-2 receptor. Moreover, [H-3]-SAL binds specifically to homogenate of AL as well as neuro-intermediate lobe obtained from lactating rats. Taken together, our data clearly suggest that SAL is synthesized in situ and this compound can Play a role in the regulation of pituitary prolactin secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:22:34