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Titolo:
Chronic pain, chronic stress and depression: Coincidence or consequence?
Autore:
Blackburn-Munro, G; Blackburn-Munro, RE;
Indirizzi:
H Lundbeck & Co AS, Depress, Dept Psychopharmacol, DK-2500 Copenhagen, Denmark H Lundbeck & Co AS Copenhagen Denmark DK-2500 K-2500 Copenhagen, Denmark Univ Edinburgh, Dept Biomed Sci, Neuroendocrinol Lab, Edinburgh EH8 9XD, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9XD Midlothian, Scotland
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 12, volume: 13, anno: 2001,
pagine: 1009 - 1023
SICI:
0953-8194(200112)13:12<1009:CPCSAD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; RAT DORSAL-ROOT; DEXAMETHASONE SUPPRESSION TEST; MESSENGER-RIBONUCLEIC-ACID; PERIPHERAL-NERVE INJURY; SPINAL-CORD; PARAVENTRICULAR NUCLEUS; GLUCOCORTICOID RECEPTOR; NEUROPATHIC PAIN;
Keywords:
antidepressants; monoamines; hypothalamic-pituitary-adrenal (HPA) axis; inflammation; neuropathy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
162
Recensione:
Indirizzi per estratti:
Indirizzo: Blackburn-Munro, RE H Lundbeck & Co AS, Depress, Dept Psychopharmacol, Ottiliavej 9, DK-2500 Copenhagen, Denmark H Lundbeck & Co AS Ottiliavej 9 Copenhagen Denmark DK-2500
Citazione:
G. Blackburn-Munro e R.E. Blackburn-Munro, "Chronic pain, chronic stress and depression: Coincidence or consequence?", J NEUROENDO, 13(12), 2001, pp. 1009-1023

Abstract

Chronic pain and depressive illness are debilitating disease states that are variably resistant to currently available therapeutic agents. Animal models of chronic pain are associated with activation of the hypothalamo-pituitary-ad renal (HPA) axis, upon which chronic pain acts as an inescapable stressor. Inescapable stress is also associated with 'depressive-like' symptoms in experimental animals. Based on reports of the comorbidity between chronic pain and depressive illness in human patients, it is possible that these disease states are linked, via chronic stress-induced HPA dysfunction. Here, we discuss the possible involvement of the HPA axis in the aetiology of both chronic pain and clinical depression, and suggest a strategy for thedevelopment of novel pharmacotherapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:31:55