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Titolo:
Isolation and structure determination of novamethymycin, a new bioactive metabolite of the methymycin biosynthetic pathway in Streptomyces venezuelae
Autore:
Zhang, QB; Sherman, DH;
Indirizzi:
Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 robiol, Minneapolis, MN 55455 USA Univ Minnesota, Inst Biotechnol, Minneapolis, MN 55455 USA Univ MinnesotaMinneapolis MN USA 55455 echnol, Minneapolis, MN 55455 USA
Titolo Testata:
JOURNAL OF NATURAL PRODUCTS
fascicolo: 11, volume: 64, anno: 2001,
pagine: 1447 - 1450
SICI:
0163-3864(200111)64:11<1447:IASDON>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHAROPOLYSPORA-ERYTHRAEA; ERYTHROMYCIN BIOSYNTHESIS; POLYKETIDE SYNTHASE; IDENTIFICATION; HYDROXYLATION; NARBOMYCIN; GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Sherman, DH Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA UnivMinnesota Minneapolis MN USA 55455 eapolis, MN 55455 USA
Citazione:
Q.B. Zhang e D.H. Sherman, "Isolation and structure determination of novamethymycin, a new bioactive metabolite of the methymycin biosynthetic pathway in Streptomyces venezuelae", J NAT PROD, 64(11), 2001, pp. 1447-1450

Abstract

Novamethymycin (9), a novel macrolide antibiotic, was isolated from Streptomyces venezuelae, the producer of methymycin (4) and neomethymycin (5). Spectroscopic analysis of 9 indicated that it is highly related to 4 and 5 but contains hydroxy groups at both C-10 and C-12 on the macrolactone ring. Bioconversion studies using the PikC cytochrome P450 hydroxylase demonstrated that 4 is converted to 9, further broadening the remarkable substrate flexibility of this enzyme.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:12:08