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Titolo:
Preparation of a technetium-99m SPECT agent for imaging the sigma-2 receptor status of solid tumors
Autore:
Mach, RH; Wheeler, KT; Blair, S; Yang, B; Day, CS; Blair, JB; Choi, SR; Kung, HF;
Indirizzi:
Wake Forest Univ, Sch Med, Div Radiol Sci, Dept Radiol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Anasazi Biomed Res Inc, Winston Salem, NC 27101 USA Anasazi Biomed Res Inc Winston Salem NC USA 27101 ton Salem, NC 27101 USA Wake Forest Univ, Dept Chem, Winston Salem, NC 27106 USA Wake Forest UnivWinston Salem NC USA 27106 , Winston Salem, NC 27106 USA Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Radiol, Philadelphia, PA 19104 USA Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Pharmacol, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
fascicolo: 13, volume: -4, anno: 2001,
pagine: 899 - 908
SICI:
0362-4803(200111)-4:13<899:POATSA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE TRANSPORTER; PROLIFERATION; EXPRESSION;
Keywords:
sigma receptors; breast cancer; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Mach, RH Wake Forest Univ, Sch Med, Div Radiol Sci, Dept Radiol, Bowman Gray Campus,Med Ctr Blvd, Winston Salem, NC 27157 USA Wake Forest Univ BowmanGray Campus,Med Ctr Blvd Winston Salem NC USA 27157
Citazione:
R.H. Mach et al., "Preparation of a technetium-99m SPECT agent for imaging the sigma-2 receptor status of solid tumors", J LABEL C R, -4(13), 2001, pp. 899-908

Abstract

The synthesis and in vitro binding of a novel Tc-99m-labeled radiotracer for imaging the sigma-2 (sigma (2)) receptor status of breast tumors is described. Structural characterization and in vitro binding studies were conducted using the corresponding rhenium surrogate, Re-2. X-ray crystallographicstudies revealed that the complexation reaction gave exclusively the syn isomer. In vitro binding studies indicated that this complex has a high affinity for sigma (2) (K-i = 13.7 nM) versus sigma (1) receptors (K-i = 1125 nM). These data indicate that [Tc-99m]2 may be a promising agent for imagingthe sigma (2) receptor status of tumors in vivo with the functional imaging technique, single photon emission computed tomography (SPECT). Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:02:54