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Titolo:
Early chemokine cascades in murine cardiac grafts regulate T cell recruitment and progression of acute allograft rejection
Autore:
Morita, K; Miura, M; Paolone, DR; Engeman, TM; Kapoor, A; Remick, DG; Fairchild, RL;
Indirizzi:
Cleveland Clin Fdn, Dept Immunol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 mmunol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Urol, Cleveland, OH 44195 USA Cleveland Clin FdnCleveland OH USA 44195 t Urol, Cleveland, OH 44195 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Pathol, Ann Arbor, MI 48109 USA Case Western Reserve Univ, Dept Pathol, Sch Med, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 5, volume: 167, anno: 2001,
pagine: 2979 - 2984
SICI:
0022-1767(20010901)167:5<2979:ECCIMC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MONOCYTE CHEMOATTRACTANT PROTEIN-1; ADHESION MOLECULE-1; GENE-EXPRESSION; ALPHA; TRANSPLANTATION; INTERLEUKIN-1; NEUTROPHILS; ACCEPTANCE; ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Fairchild, RL Cleveland Clin Fdn, Dept Immunol, 9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin Fdn 9500 Euclid Ave Cleveland OH USA 44195 SA
Citazione:
K. Morita et al., "Early chemokine cascades in murine cardiac grafts regulate T cell recruitment and progression of acute allograft rejection", J IMMUNOL, 167(5), 2001, pp. 2979-2984

Abstract

The identification of early inflammatory events after transplant in solid tissue organ grafts that may direct T cell recruitment and promote acute allograft rejection remain largely unknown. To better understand temporal aspects of early inflammatory events in vascularized organ grafts, we tested the intragraft expression of four different chemokines in heterotopically transplanted Ad (H-2(n)) and syngeneic heart grafts in C57BL/6 (H-2(b)) recipient mice from 1.5 to 48 h after transplant. Similar temporal expression patterns and equivalent levels of chemokine expression were observed in both syngeneic and allogeneic cardiac allografts during this time period. Expression of the neutrophil chemoattractant growth-related oncogene ce (KC) was observed first and reached peak levels by 6 h after transplant and was followed by the monocyte/macrophage chemoattractant protein-1 (JE) and then macrophage inflammatory proteins 1 beta and 1 alpha. Administration of rabbit KC antiserum to allograft recipients within 30 min of cardiac transplantation attenuated downstream events including intra-allograft expression of theT cell chemoattractants IFN-gamma -inducible protein-10 and monokine induced by IFN-gamma, cellular infiltration into the allograft, and graft rejection. Similarly, depletion of recipient neutrophils at the time of transplantation significantly extended allograft survival from day 8 to 10 in control-treated recipients up to day 21 after transplant. These results indicate the induction of highly organized cascades of neutrophil and macrophage chemoattractants in cardiac grafts and support the proposal that early inflammatory events are required for optimal recruitment of T cells into allografts during the progression of acute rejection of cardiac allografts.

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Documento generato il 14/07/20 alle ore 12:35:28