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Titolo:
Circulating tumour necrosis factor-alpha and interferon-gamma are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue
Autore:
Kerr, JR; Barah, F; Mattey, DL; Laing, I; Hopkins, SJ; Hutchinson, IV; Tyrrell, DAJ;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Sch Med, Natl Heart & Lung Inst, Royal Brompton Hosp,Dept Microbiol, London SW3 6NP, England Univ LondonImperial Coll Sci Technol & Med London England SW3 6NP gland Univ Manchester, Dept Virol, Manchester, Lancs, England Univ Manchester Manchester Lancs England rol, Manchester, Lancs, England Univ Manchester, N Western Injury Res Ctr, Manchester, Lancs, England UnivManchester Manchester Lancs England Ctr, Manchester, Lancs, England Univ Manchester, Sch Biol Sci, Manchester, Lancs, England Univ ManchesterManchester Lancs England Sci, Manchester, Lancs, England Staffordshire Rheumatol Ctr, Stoke On Trent, Staffs, England StaffordshireRheumatol Ctr Stoke On Trent Staffs England taffs, England Manchester Royal Infirm, Dept Biochem, Manchester M13 9WL, Lancs, England Manchester Royal Infirm Manchester Lancs England M13 9WL , Lancs, England MRC, Common Cold Unit, Salisbury, Wilts, England MRC Salisbury Wilts England Common Cold Unit, Salisbury, Wilts, England
Titolo Testata:
JOURNAL OF GENERAL VIROLOGY
, volume: 82, anno: 2001,
parte:, 12
pagine: 3011 - 3019
SICI:
0022-1317(200112)82:<3011:CTNFAI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TNF-ALPHA; HERPES-SIMPLEX; VIRUS; APOPTOSIS; CELLS; PROTEIN; INTERLEUKIN-6; CYTOKINES; RESPONSES; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Kerr, JR Univ London Imperial Coll Sci Technol & Med, Sch Med, Natl Heart & Lung Inst, Royal Brompton Hosp,Dept Microbiol, Sydney St, London SW3 6NP,England Univ London Imperial Coll Sci Technol & Med Sydney St London England SW3 6NP
Citazione:
J.R. Kerr et al., "Circulating tumour necrosis factor-alpha and interferon-gamma are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue", J GEN VIROL, 82, 2001, pp. 3011-3019

Abstract

To investigate whether cytokine responses may have a bearing on the symptoms and outcome of parvovirus B19 infection, circulating cytokines were measured during acute infection (n = 51), follow-up of acute infection (n = 39)and in normal healthy controls (n = 50). At acute B19 virus infection (serum anti-B19 IgM-positive), patients ranged in age from 4 to 54 years, with a mean age of 28-2 years. The male: female ratio was 1:41 and symptoms wererash (n = 15), arthralgia (n = 31), fatigue (n = 8), lymphadenopathy (n = 4), foetal hydrops (n = 3), transient aplastic crisis (n = 2), neutropenia (n = 2), myelodysplasia (n = 1), thrombocytopenia (n = 1) and pancytopenia (n = 1). Of these patients, 39 were contacted after a follow-up period of 2-37 months (mean of 22-5 months). In comparison with normal controls, detectable IL-6 was associated with acute B19 virus infection (26%; P = 0.0003),but not with follow-up (6%; P = 0.16). Detection of interferon (IFN)-gammawas associated with acute B19 virus infection (67%; P < 0.0001) and follow-up (67%;P < 0.0001). Detection of tumour necrosis factor (TNF)-alpha was associated with acute B19 virus infection (49%; P < 0.0001) and follow-up (56%; P < 0.0001). IL-1 beta was detected in acute infection (20%), but not at follow-up. At acute B19 virus infection, detection of serum/plasma IL-6 was associated with rheumatoid factor (P = 0.038) and IFN-gamma (greater than or equal to 7 pg/ml) was associated with fatigue in those patients of > 15 years of age (P = 0.022). At follow-up, fatigue was associated with IFN-gamma (> 7 pg/ml) and/or TNF-alpha (> 40 pg/ml) (P = 0.0275). Prolonged upregulation of serum IFN-gamma and TNF-alpha appears to represent a consistenthost response to symptomatic B19 virus infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 20:01:15