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Titolo:
Molecular epidemiology of dengue type 2 virus in Venezuela: evidence for in situ virus evolution and recombination
Autore:
Uzcategui, NY; Camacho, D; Comach, G; de Uzcategui, RC; Holmes, EC; Gould, EA;
Indirizzi:
Inst Virol & Environm Microbiol, Oxford OX1 3SR, England Inst Virol & Environm Microbiol Oxford England OX1 3SR OX1 3SR, England Univ Oxford, Dept Zool, Oxford OX1 3PS, England Univ Oxford Oxford England OX1 3PS d, Dept Zool, Oxford OX1 3PS, England Lab Reg Diagnost & Invest Dengue & Ortas Enfermed, Maracay, Estado Aragua,Venezuela Lab Reg Diagnost & Invest Dengue & Ortas Enfermed Maracay EstadoAragua Venezuela Inst Venezolano Invest Cient, Ctr Microbiol & Biol Celular, Caracas 1020A,Venezuela Inst Venezolano Invest Cient Caracas Venezuela 1020A cas 1020A,Venezuela
Titolo Testata:
JOURNAL OF GENERAL VIROLOGY
, volume: 82, anno: 2001,
parte:, 12
pagine: 2945 - 2953
SICI:
0022-1317(200112)82:<2945:MEODT2>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-SEQUENCES; MONOCLONAL-ANTIBODIES; HEMORRHAGIC-FEVER; NUCLEOTIDE; PROTEINS; GENOTYPE; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Gould, EA Inst Virol & Environm Microbiol, Mansfield Rd, Oxford OX1 3SR, England Inst Virol & Environm Microbiol Mansfield Rd Oxford England OX1 3SR
Citazione:
N.Y. Uzcategui et al., "Molecular epidemiology of dengue type 2 virus in Venezuela: evidence for in situ virus evolution and recombination", J GEN VIROL, 82, 2001, pp. 2945-2953

Abstract

Epidemic outbreaks of dengue fever (DF) were first recorded in Venezuela in 1978 and were followed by the emergence of dengue haemorrhagic fever (DHF) outbreaks in 1989. To gain a better understanding of the nature of these epidemics, the complete envelope (E) gene sequence of 34 Venezuelan dengue type 2 (DEN-2) viruses, isolated between 1997 and 2000 was determined. Of these isolates, 16 were from patients with DF and 17 were from patients diagnosed with DHF. There were no diagnostic sequence differences between them,suggesting that the E gene alone does not determine disease severity. These sequence data were also used in phylogenetic comparisons with a global sample of DEN-2 viruses, including strains collected previously from Venezuela. This analysis revealed that the ancestors of the Venezuelan viruses wereAsian in origin, implying that a DEN-2 virus strain from this region was introduced into Venezuela and the wider Caribbean region during the late 1970s or the early 1980s. The phylogenetic trees further indicate that evolution of DEN-2 virus in Venezuela has occurred in situ, with differentiation into a number of distinct but co-circulating lineages, rather than the repeated introduction of new strains from other localities. By incorporating additional sequence data from the virus capsid, premembrane and membrane genes, evidence is provided that a single Venezuelan strain sequenced previously, designated Mara4, is a recombinant virus, incorporating genome sequence from Venezuelan and Asian parental viruses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:28:37