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Titolo:
Comparison of genomic and predicted amino acid sequences of respiratory and enteric bovine coronaviruses isolated from the same animal with fatal shipping pneumonia
Autore:
Chouljenko, VN; Lin, XQ; Storz, J; Kousoulas, KG; Gorbalenya, AE;
Indirizzi:
Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Baton Rouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 , Baton Rouge, LA 70803 USA Sci Applicat Int Corp, Adv Biomed Comp Ctr, NCI, Frederick, MD 21702 USA Sci Applicat Int Corp Frederick MD USA 21702 NCI, Frederick, MD 21702 USA
Titolo Testata:
JOURNAL OF GENERAL VIROLOGY
, volume: 82, anno: 2001,
parte:, 12
pagine: 2927 - 2933
SICI:
0022-1317(200112)82:<2927:COGAPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS; INFECTIOUS-BRONCHITIS VIRUS; INDUCED CELL-FUSION; OPEN READING FRAME; POLYMERASE GENE; RNA-POLYMERASE; MONOCLONAL-ANTIBODIES; SPIKE GLYCOPROTEIN; IDENTIFICATION; POLYPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Kousoulas, KG Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, BatonRouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 LA 70803 USA
Citazione:
V.N. Chouljenko et al., "Comparison of genomic and predicted amino acid sequences of respiratory and enteric bovine coronaviruses isolated from the same animal with fatal shipping pneumonia", J GEN VIROL, 82, 2001, pp. 2927-2933

Abstract

The complete genome sequences are reported here of two field isolates of bovine coronavirus (BCoV), which were isolated from respiratory and intestinal samples of the same animal experiencing fatal pneumonia during a bovine shipping fever epizootic. Both genomes contained 31028 nucleotides and included 13 open reading frames (ORFs) flanked by 5'- and 3'-untranslated regions (UTRs). ORF1a and ORF1 b encode replicative polyproteins pp1a and pp1ab,respectively, that contain all of the putative functional domains documented previously for the closest relative, mouse hepatitis virus. The genomes of the BCoV isolates differed in 107 positions, scattered throughout the genome except the 5'-UTR. Differences in 25 positions were non-synonymous andwere located in all proteins except pp 1 b. Six replicase mutations were identified within or immediately downstream of the predicted largest pp1a-derived protein, p195/p210. Single amino acid changes within p195/p210 as well as within the S glycoprotein might contribute to the different phenotypesof the BCoV isolates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:23:59