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Titolo:
Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C -> A polymorphism in intron 1 of the CYP1A2 gene: Effect of grapefruit juice and low-dose fluvoxamine
Autore:
Ozdemir, V; Kalow, W; Okey, AB; Lam, MSM; Albers, LJ; Reist, C; Fourie, J; Posner, P; Collins, EJ; Roy, R;
Indirizzi:
Univ Toronto, Dept Pharmacol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 macol, Toronto, ON M5S 1A8, Canada Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 chiat, Toronto, ON M5S 1A8, Canada Univ Calif Irvine, Long Beach Vet Adm Med Ctr, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 t Adm Med Ctr, Irvine, CA 92717 USA Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 & Human Behav, Irvine, CA 92717 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 6, volume: 21, anno: 2001,
pagine: 603 - 607
SICI:
0271-0749(200112)21:6<603:TTCIAW>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-DESMETHYLCLOZAPINE; IN-VITRO; SCHIZOPHRENIA; INHIBITOR; CYTOCHROME-P450; CAFFEINE; PHARMACOGENETICS; ANTIDEPRESSANTS; DISPOSITION; NEFAZODONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kalow, W Univ Toronto, Dept Pharmacol, 1 Kings Coll Circle,Med Sci Bldg,Room 4206, Toronto, ON M5S 1A8, Canada Univ Toronto 1 Kings Coll Circle,Med Sci Bldg,Room 4206 Toronto ON Canada M5S 1A8
Citazione:
V. Ozdemir et al., "Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C -> A polymorphism in intron 1 of the CYP1A2 gene: Effect of grapefruit juice and low-dose fluvoxamine", J CL PSYCH, 21(6), 2001, pp. 603-607

Abstract

Antipsychotic response to clozapine varies markedly among patients with schizophrenia. The disposition of clozapine is dependent, in part, on the cytochrome P-450 (CYP) 1A2 enzyme in vivo. In theory, a very high CYP1A2 activity may lead to subtherapeutic concentrations and treatment resistance to clozapine. This prospective case study evaluates the clinical significance of ultrarapid CYP1A2 activity and a recently discovered single nucleotide (C--> A) polymorphism in intron 1 of the CYP1A2 gene (CYP1A2*F) for treatment resistance to clozapine. In addition, we describe the effect of grapefruit juice or low-dose fluvoxamine (25-50 mg/d) coadministration on clozapine and active metabolite norclozapine steady-state plasma concentration and antipsychotic response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:08:38