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Titolo:
Pharmacoepidemiologic investigation of a clonazepam-carbamazepine interaction by mixed effect modeling using routine clinical pharmacokinetic data inJapanese patients
Autore:
Yukawa, E; Nonaka, T; Yukawa, M; Ohdo, S; Higuchi, S; Kuroda, T; Goto, Y;
Indirizzi:
Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Clin Pharmacokinet, Higashi Ku,Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 net, Higashi Ku,Fukuoka 8128582, Japan Fukuoka Univ Hosp, Dept Pharm, Fukuoka, Japan Fukuoka Univ Hosp Fukuoka Japan a Univ Hosp, Dept Pharm, Fukuoka, Japan Fukuoka Univ, Fac Pharmaceut Sci, Fukuoka 81401, Japan Fukuoka Univ Fukuoka Japan 81401 ac Pharmaceut Sci, Fukuoka 81401, Japan
Titolo Testata:
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 6, volume: 21, anno: 2001,
pagine: 588 - 593
SICI:
0271-0749(200112)21:6<588:PIOACI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-PEAK APPROACH; POPULATION PHARMACOKINETICS; DRUG-INTERACTIONS; VALPROIC ACID; PLASMA; METABOLISM; FEASIBILITY; ALPRAZOLAM; PHENYTOIN; EPILEPSY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Yukawa, E Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Clin Pharmacokinet, Higashi Ku,3-1-1 Maidashi, Fukuoka 8128582, Japan Kyushu Univ 3-1-1 MaidashiFukuoka Japan 8128582 8128582, Japan
Citazione:
E. Yukawa et al., "Pharmacoepidemiologic investigation of a clonazepam-carbamazepine interaction by mixed effect modeling using routine clinical pharmacokinetic data inJapanese patients", J CL PSYCH, 21(6), 2001, pp. 588-593

Abstract

Nonlinear mixed effects modeling was used to estimate the effects of clonazepam-carbamazepine interaction on clearance values using 359 serum levels gathered from 183 pediatric and adult epileptic patients (age range, 0.3-26.8 years) during their clinical routine care. Patients received the administration of clonazepam and/or carbamazepine. The final model describing clonazepam clearance was CL = 179.0 (. ) TBW-0.231 (.) 1.22(CBZ), where CL is total body clearance (mL/kg/h) and TBW is total body weight (kg); CBZ = 1 forconcomitant administration of carbamazepine and CBZ = zero otherwise. The final model describing carbamazepine clearance was CL = 92.7 (. ) TBW-0.394 (. ) DOSE0.397 (.) 0.795(CZP), where DOSE is the daily dose of carbamazepine(mg/kg/day); CZP = 1 for concomitant administration of clonazepam and CZP = zero otherwise. Concomitant administration of clonazepam and carbamazepine resulted in a 22% increase in clonazepam clearance and a 20.5% decrease in carbamazepine clearance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:20:10