Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Contrasting effects of midazolam on induction of heat shock protein 27 by vasopressin and heat in aortic smooth muscle cells
Autore:
Tanabe, K; Kozawa, O; Niwa, M; Yamomoto, T; Matsuno, H; Ito, H; Kato, K; Dohi, S; Uematsu, T;
Indirizzi:
Gifu Univ, Sch Med, Dept Pharmacol, Gifu 5008705, Japan Gifu Univ Gifu Japan 5008705 ch Med, Dept Pharmacol, Gifu 5008705, Japan Gifu Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Gifu 500, Japan GifuUniv Gifu Japan 500 pt Anesthesiol & Crit Care Med, Gifu 500, Japan Aichi Human Serv Ctr, Inst Dev Res, Kasugai, Aichi, Japan Aichi Human ServCtr Kasugai Aichi Japan Dev Res, Kasugai, Aichi, Japan
Titolo Testata:
JOURNAL OF CELLULAR BIOCHEMISTRY
fascicolo: 1, volume: 84, anno: 2002,
pagine: 39 - 46
SICI:
0730-2312(2002)84:1<39:CEOMOI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-B-CRYSTALLIN; P38 MAP KINASE; MOLECULAR CHAPERONES; STRESS; HSP27; PROPOFOL; HEAT-SHOCK-PROTEIN-27; EXPRESSION; PHOSPHORYLATION; MECHANISMS;
Keywords:
aortic smooth muscle cells; cell culture; heat shock protein; midazolam; vasopressin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Kozawa, O Gifu Univ, Sch Med, Dept Pharmacol, Gifu 5008705, Japan Gifu Univ Gifu Japan 5008705 pt Pharmacol, Gifu 5008705, Japan
Citazione:
K. Tanabe et al., "Contrasting effects of midazolam on induction of heat shock protein 27 by vasopressin and heat in aortic smooth muscle cells", J CELL BIOC, 84(1), 2002, pp. 39-46

Abstract

We previously showed that vasopressin stimulates the induction of heat shock protein (HSP) 27, a low molecular-weight HSP, through protein kinase C activation in aortic smooth muscle A10 cells. In the present study, we examined the effects of midazolam, an intravenous anesthetic, on the HSP27 induction stimulated by vasopressin, heat, or sodium arsenite (arsenite) in A10 cells. Midazolam inhibited the accumulation of HSP27 induced by vasopressinor 12-O-tetradecanoylphorbol 13-acetate (TPA), a direct activator of protein kinase C. Midazolam also reduced the vasopressin-induced level of the mRNA for HSP27. In contrast, midazolam enhanced the HSP27-accumulation induced by heat or arsenite. Miclazolam also enhanced the heat-increased level ofthe mRNA for HSP27. However, midazolam had no effect on the dissociation of the aggregated form of HSP27 following stimulation by vasopressin, heat, or arsenite. These results suggest that midazolam suppresses vasopressin-stimulated HSP27 induction in vascular smooth muscle cells, and that this inhibitory effect is exerted at a point downstream from protein kinase C. In contrast, midazolam enhanced heat- or arsenite-stimulated HSP27 induction. Thus, midazolam has dual effects on the HSP27 induction stimulated by various stresses in vascular smooth muscle cells. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:59:34