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Titolo:
Low dose systemic heparinization combined with heparin-coated extracorporeal circulation - Effects related to platelets
Autore:
Mirow, N; Brinkmann, T; Minami, K; Tenderich, G; Schulte-Eistrup, S; Kleesiek, K; Korfer, R;
Indirizzi:
Ruhr Univ Bochum, Heart Ctr NRW, Dept Thorac & Cardiovasc Surg, Clin Thorac & Cardiovasc Surg, D-32545 Bad Oeynhausen, Germany Ruhr Univ Bochum Bad Oeynhausen Germany D-32545 Bad Oeynhausen, Germany
Titolo Testata:
JOURNAL OF CARDIOVASCULAR SURGERY
fascicolo: 5, volume: 42, anno: 2001,
pagine: 579 - 585
SICI:
0021-9509(200110)42:5<579:LDSHCW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOPULMONARY BYPASS; HEART OPERATIONS; ACTIVATION; CIRCUITS; ANTICOAGULATION; COMPLEMENT;
Keywords:
cardiopulmonary bypass; extracorporeal circulation; heparin; coated materials, biocompatible; heparin, low molecular weight; blood coagulation; blood platelets; coronary artery bypass;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Mirow, N Ruhr Univ Bochum, Heart Ctr NRW, Dept Thorac & Cardiovasc Surg, Clin Thorac & Cardiovasc Surg, Georgstr 11, D-32545 Bad Oeynhausen, Germany Ruhr Univ Bochum Georgstr 11 Bad Oeynhausen Germany D-32545 many
Citazione:
N. Mirow et al., "Low dose systemic heparinization combined with heparin-coated extracorporeal circulation - Effects related to platelets", J CARD SURG, 42(5), 2001, pp. 579-585

Abstract

Background. A heparin coated cardiopulmonary bypass system combined with full and low dose systemic heparinization in coronary bypass surgery was investigated in a prospective, randomised study. Roller pumps, coronary suction and an open cardiotomy reservoir were used. Methods. One hundred and nineteen patients were divided into 3 groups: group A (n=39) had a standard uncoated extracorporeal circulation (ECC)-set and systemic heparin was given in an initial dose of 400 IE/kg body weight. During ECC activated clotting time (ACT) was kept at greater than or equal to 480 sec. Group B (n=42) had the same ECC-set completely coated with low molecular weight heparin, i.v. heparin was administered in the same dose as in group A, ACT was again kept at greater than or equal to 480 sec. Group C(n=38) had the same coated ECC set as group B, but ix. heparin was reducedto 150 IE/kg and during ECC ACT was maintained of greater than or equal to240 sec. Results. Platelet decrease was significantly less in both groups utilizingcoated circuitry as compared to control group A. Activation of thrombocytes as marked by beta -thromboglobulin (not PF4) was significantly decreased in patients treated with coated circuits combined with low dose systemic heparinization and postoperative bleeding was significantly reduced. Conclusions. We conclude that in heparin coated extracorporeal circulationcombined with either full dose or reduced systemic heparinization comparedto uncoated circuits platelet count reduction is significantly less. Platelet activation as marked by beta -thromboglobulin and postoperative blood loss are decreased with coated equipment and low i.v. heparinization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:50:48