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Titolo:
Biodegradable dextran-polylactide hydrogel networks: Their swelling, morphology and the controlled release of indomethacin
Autore:
Zhang, YL; Chu, CC;
Indirizzi:
Cornell Univ, Dept Text, Fiber & Polymer Sci Program, Ithaca, NY 14853 USACornell Univ Ithaca NY USA 14853 olymer Sci Program, Ithaca, NY 14853 USA Cornell Univ, Apparel & Biomed Engn Program, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 iomed Engn Program, Ithaca, NY 14853 USA
Titolo Testata:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
fascicolo: 2, volume: 59, anno: 2002,
pagine: 318 - 328
SICI:
0021-9304(200202)59:2<318:BDHNTS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POROUS POLY(L-LACTIDE) MEMBRANES; METHOXY POLY(ETHYLENE GLYCOL); GUIDED TISSUE REGENERATION; BLOCK COPOLYMERIC MICELLE; CONTROLLED DRUG-DELIVERY; IN-VITRO; POLY(ACRYLIC ACID); POLY(LACTIC ACID); SYSTEMS; MICROPARTICLES;
Keywords:
dextran; polylactide; polymer network; hydrogel; swelling; biodegradation; indomethacin; photocrosslinking; drug release; morphology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Chu, CC Cornell Univ, Dept Text, Fiber & Polymer Sci Program, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 ci Program, Ithaca, NY 14853 USA
Citazione:
Y.L. Zhang e C.C. Chu, "Biodegradable dextran-polylactide hydrogel networks: Their swelling, morphology and the controlled release of indomethacin", J BIOMED MR, 59(2), 2002, pp. 318-328

Abstract

Biodegradable polymer hydrogel networks based on hydrophilic dextran derivative of allyl isocyanate (dex-AI) and hydrophobic poly (D,L) lactide diacrylate macromer (PDLLAM) were synthesized, and their swelling and morphological properties were studied. During a 2-day incubation, the higher the PDLLAM composition in the hydrogel, the slower the swelling as well as the lower the extent of swelling were. A 3D porous network structure was observed by scanning electron microscope. The rate of formation of this 3D porous network structure depended on the hydrophilicity of the components, their composition ratio, and the degradation time. The highly hydrophilic dex-AI component facilitated the formation of this 3D porous network structure at an earlier immersion period, while the degradability,of the PDLLAM component would make this 3D porous network structure more open at a later immersion period. Indomethacin, a low molecular weight and moderately hydrophobic drug,was incorporated into the hydrogels for the release study in pH 7.4 phosphate buffer solution at 37 degreesC. The release kinetics suggested, as the PDLLAM composition increased, the indomethacin diffusion coefficient (D) and release half life time (t(1/2)) decreased, while the release index n increased. The controlled release mechanism was determined by the combination of three factors: the rate and degree of formation of swelling-induced 3D porous structure in the hydrogel, the hydrolytic degradation of PDLLAM components, and the hydrophobic interaction between PDLLAM and IDM. (C) 2001 JohnWiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:52:29