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Titolo:
In situ hydrogelation of photocurable gelatin and drug release
Autore:
Okino, H; Nakayama, Y; Tanaka, M; Matsuda, T;
Indirizzi:
Kyushu Univ, Grad Sch Med, Dept Biomed Engn, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 gn, Higashi Ku, Fukuoka 8128582, Japan Natl Cardiovasc Ctr, Res Inst, Dept Bioengn, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr Suita Osaka Japan 5658565 Suita, Osaka 5658565, Japan Kyushu Univ, Grad Sch Med, Dept Surg & Oncol, Higashi Ku, Fukuoka 8128582,Japan Kyushu Univ Fukuoka Japan 8128582 col, Higashi Ku, Fukuoka 8128582,Japan
Titolo Testata:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
fascicolo: 2, volume: 59, anno: 2002,
pagine: 233 - 245
SICI:
0021-9304(200202)59:2<233:ISHOPG>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLY(ETHYLENE GLYCOL) DIACRYLATE; IN-VITRO; GROWTH-FACTOR; PHOTOPOLYMERIZATION; ANGIOGENESIS; INHIBITOR; MATRIX; TISSUE; BONE;
Keywords:
photoreactive gelatin; hydrogel; visible-light irradiation; local drug delivery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuda, T Kyushu Univ, Grad Sch Med, Dept Biomed Engn, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan Kyushu Univ 3-1-1 Maidashi Fukuoka Japan 8128582 128582, Japan
Citazione:
H. Okino et al., "In situ hydrogelation of photocurable gelatin and drug release", J BIOMED MR, 59(2), 2002, pp. 233-245

Abstract

We devised an in situ tissue-adhesive, drug-release technology based on a photoreactive gelatin, which allows in situ drug-incorporated gel formationon living tissues and sustained drug release directly on diseased tissues. Styrene-derivatized gelatins, synthesized by condensation reaction of gelatin with 4-vinylbenzoic acid, were photopolymerized in the presence of a water-soluble camphorquinone derivative as a photoinitiator upon visible-light irradiation to form swollen gels. Using albumin as a drug model, gelationcharacteristics and drug-release characteristics easily were manipulated by material variables, formulation variables, and operation variables. Tissue adhesivity of the gel was superior to that of fibrin glue. The biologic response, which was evaluated by intraperitoneal implantation in rats, showed that the gel was biodegraded and biosorbed, without cytotoxicity, within a few months after implantation. An in situ processable tissue-adhesive local drug release system effectively may be used to help inhibit tumor recurrence. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:17:07