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Titolo:
Study on the anticancer drug 5-fluorouracil-conjugated polyaspartamide containing hepatocyte-targeting group
Autore:
Yan, GP; Zhuo, RX; Zheng, CY;
Indirizzi:
Wuhan Univ, Dept Chem, Minist Educ, Lab Biomed Polymer Mat, Wuhan 430072, Peoples R China Wuhan Univ Wuhan Peoples R China 430072 t, Wuhan 430072, Peoples R China Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China Wuhan Univ Wuhan Peoples R China 430072 i, Wuhan 430072, Peoples R China
Titolo Testata:
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
fascicolo: 4, volume: 16, anno: 2001,
pagine: 277 - 293
SICI:
0883-9115(200107)16:4<277:SOTAD5>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIVIRAL AGENT; DERIVATIVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Zhuo, RX Wuhan Univ, Dept Chem, Minist Educ, Lab Biomed Polymer Mat, Wuhan430072, Peoples R China Wuhan Univ Wuhan Peoples R China 430072 430072, Peoples R China
Citazione:
G.P. Yan et al., "Study on the anticancer drug 5-fluorouracil-conjugated polyaspartamide containing hepatocyte-targeting group", J BIOACT C, 16(4), 2001, pp. 277-293

Abstract

Anticancer conjugates of 5-fluorouracil (5-Fu) and polyaspartamide, containing pyridoxamine as the hepatocyte-targeting group, were synthesized and characterized. Their sustained release properties and biodistribution were evaluated. The 5-Fu was targeted to specific organs, such as the liver, and had a sustained in vitro release rate in PBS. In vitro cytotoxicity assay showed that the polymeric drugs exhibited low cytotoxicity to the human liver cells (L-02). These polymeric drugs possess high anticancer efficiencies and induced apoptosis in the human hepatic tumor cells (Bel-7204).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 19:49:37