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Titolo:
Genome and Hormones: Gender Differences in Physiology Selected Contribution: Time-dependent hypoxic respiratory responses in female rats are influenced by age and by the estrus cycle
Autore:
Zabka, AG; Behan, M; Mitchell, GS;
Indirizzi:
Univ Wisconsin, Sch Vet Med, Dept Comparat Biosci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 omparat Biosci, Madison, WI 53706 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2831 - 2838
SICI:
8750-7587(200112)91:6<2831:GAHGDI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM FACILITATION; SLEEP-APNEA; SEROTONIN TRANSPORTER; VENTILATORY RESPONSE; MOTOR OUTPUT; STIMULATION; SYSTEM; NEUROTRANSMITTERS; TESTOSTERONE; MOTONEURONS;
Keywords:
respiratory control; plasticity; hypoxia; serotonin; gender;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Zabka, AG Univ Wisconsin, Sch Vet Med, Dept Comparat Biosci, 2015 Linden Dr W, Madison, WI 53706 USA Univ Wisconsin 2015 Linden Dr W Madison WI USA 53706 I 53706 USA
Citazione:
A.G. Zabka et al., "Genome and Hormones: Gender Differences in Physiology Selected Contribution: Time-dependent hypoxic respiratory responses in female rats are influenced by age and by the estrus cycle", J APP PHYSL, 91(6), 2001, pp. 2831-2838

Abstract

Age affects time-dependent respiratory responses to episodic hypoxia in male rats, particularly long-term facilitation (LTF), a serotonin-dependent respiratory "memory" [Zabka AG, Behan M and Mitchell GS, J Physiol (Lond) 531: 509, 2001]. Because age and gender influence serotonergic function, we tested the hypotheses that the short-term hypoxic response (STHR), posthypoxia frequency decline (PHFD) and LTF of phrenic and hypoglossal (XII) motor output change with age and stage of the estrus cycle in female rats. Young (3-4 mo) and middle-aged (13 mo) female Sprague-Dawley rats were anesthetized, paralyzed, vagotomized, and ventilated. STHR was measured during and PHFD after the first of three 5-min episodes of isocapnic hypoxia (arterial Po-2 35-45 Torr). LTF was assessed 60 min postepisodic hypoxia. Phrenic and XII STHR increased with age (P < 0.05). PHFD was unaffected by age or gender. Phrenic LTF increased with age in both estrus and diestrus (P < 0.05), whereas XII LTF increased in middle-aged female rats during diestrus only. Age and gender influence time-dependent hypoxic phrenic and XII responses ina complex manner.

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Documento generato il 23/01/20 alle ore 18:47:04