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Titolo:
Genome and hormones: Gender differences in physiology selected contribution: Effects of gender on reduced-size liver ischemia and reperfusion injury
Autore:
Harada, H; Pavlick, KP; Hines, IN; Hoffman, JM; Bharwani, S; Gray, L; Wolf, RE; Grisham, MB;
Indirizzi:
Louisiana State Univ, Hlth Sci Ctr, Dept Cellular & Mol Physiol, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 ol, Shreveport, LA 71130 USA Louisiana State Univ, Hlth Sci Ctr, Dept Med, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 ed, Shreveport, LA 71130 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2816 - 2822
SICI:
8750-7587(200112)91:6<2816:GAHGDI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; RAT-LIVER; ISCHEMIA/REPERFUSION INJURY; HEPATOCELLULAR-CARCINOMA; TRAUMA-HEMORRHAGE; RECIPIENT GENDER; ESTROGEN; TRANSPLANTATION; RECEPTOR; REGENERATION;
Keywords:
inflammation; estrogen; ovariectomy; nitric oxide; reactive oxygen species;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Grisham, MB Louisiana State Univ, Hlth Sci Ctr, Dept Cellular & Mol Physiol, POB 33932, Shreveport, LA 71130 USA Louisiana State Univ POB 33932 Shreveport LA USA 71130 130 USA
Citazione:
H. Harada et al., "Genome and hormones: Gender differences in physiology selected contribution: Effects of gender on reduced-size liver ischemia and reperfusion injury", J APP PHYSL, 91(6), 2001, pp. 2816-2822

Abstract

Hepatic resection with concomitant periods of ischemia and reperfusion (I/R) is a common occurrence in resectional surgery as well as reduced-size liver transplantation (e.g., split liver or living donor transplantation). However, the I/R induced by these types of surgical manipulations may impair liver regeneration, ultimately leading to liver failure. The objectives of the study were to develop a murine model of reduced-size liver I/R and assess the role of gender in this model of hepatocellular injury. We found that100% of female mice survived the surgery indefinitely, whereas all male mice had greater initial liver injury and died within 5 days after surgery. The protective effect observed in females appeared to be due to ovarian 17 beta -estradiol, as ovariectomy of females or administration of a selective estrogen antagonist to female mice resulted in enhanced liver injury and greater mortality following reduced-size liver I/R, Conversely, 17 beta -estradiol-treated male mice exhibited less hepatocellular damage and survived indefinitely. Taken together, these data demonstrate an estrogen-mediated protective pathway(s) that limits or attenuates hepatocellular injury inducedby reduced-size liver I/R.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:12:34