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Titolo:
Genome and hormones: Gender differences in physiology selected contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis
Autore:
Hayashi, T; Faustman, DL;
Indirizzi:
Massachusetts Gen Hosp E, Immunobiol Lab, Charlestown, MA 02129 USA Massachusetts Gen Hosp E Charlestown MA USA 02129 arlestown, MA 02129 USA Harvard Univ, Sch Med, Charlestown, MA 02129 USA Harvard Univ CharlestownMA USA 02129 Sch Med, Charlestown, MA 02129 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2804 - 2815
SICI:
8750-7587(200112)91:6<2804:GAHGDI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; UBIQUITIN-PROTEASOME PATHWAY; INTERFERON-GAMMA; SUBUNIT-X; CLASS-I; EMBRYONIC LETHALITY; SIGNAL-TRANSDUCTION; TARGETED DISRUPTION; LIVER DEGENERATION; PANCREATIC-ISLETS;
Keywords:
proteasome; nuclear factor-kappa B; Type 1 diabetes, tumor necrosis factor-alpha; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Faustman, DL Massachusetts Gen Hosp E, Immunobiol Lab, Bldg 149,13th St, Charlestown, MA 02129 USA Massachusetts Gen Hosp E Bldg 149,13th St Charlestown MA USA 02129
Citazione:
T. Hayashi e D.L. Faustman, "Genome and hormones: Gender differences in physiology selected contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis", J APP PHYSL, 91(6), 2001, pp. 2804-2815

Abstract

Recent results in an animal model of autoimmune diabetes, the nonobese diabetic (NOD) mouse, suggest a hypothesis to explain the role of major histocompatibility complex (MHC) in autoimmunity. The genome MHC region contains immune response genes that are important for T cell education and antigen presentation by MHC molecules. Two such genes encoding the LMP2 and LMP7 proteasome subunits are located in this high-risk MHC genomic region. Proteasome containing the LMP2 subunit is essential for T cell education and proteolytically activates transcription factor nuclear factor-kappaB. Splenocytesof NOD mouse with marked female specificity for disease expression are defective in LMP2 expression. The spontaneous defective LMP2 expression in NODmice, which is gender biased toward female cohorts, is restricted to select lymphoid and myeloid cells and is developmentally controlled with loweredLMP2 protein and heightened tumor necrosis factor-alpha -induced apoptosis. These defects are apparent only after similar to7 wk of age. These data suggest a proteasome role in autoimmune progression, and a gender developmental and lineage restriction of LMP2 expression may contribute to the diverse autoimmune characteristics preferentially observed in female NOD mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:45:44