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Titolo:
Genome and hormones: Gender differences in physiology - Invited review: Pharmacogenetics of estrogen replacement therapy
Autore:
Herrington, DM; Klein, KP;
Indirizzi:
Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med Cardiol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2776 - 2784
SICI:
8750-7587(200112)91:6<2776:GAHGDI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-V-LEIDEN; ACTIVATED PROTEIN-C; CORONARY HEART-DISEASE; DEEP VENOUS THROMBOSIS; BONE-MINERAL DENSITY; POSTMENOPAUSAL CAUCASIAN WOMEN; RECEPTOR GENETIC-POLYMORPHISM; FRAGMENT-LENGTH-POLYMORPHISM; INHIBITOR-1 PAI-1 GENE; VII COAGULANT ACTIVITY;
Keywords:
estrogen receptor-alpha; polymorphisms; postmenopausal women; thrombosis; risk factors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
115
Recensione:
Indirizzi per estratti:
Indirizzo: Herrington, DM Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med Cardiol, Med Ctr Blvd, Winston Salem, NC 27157 USA Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 SA
Citazione:
D.M. Herrington e K.P. Klein, "Genome and hormones: Gender differences in physiology - Invited review: Pharmacogenetics of estrogen replacement therapy", J APP PHYSL, 91(6), 2001, pp. 2776-2784

Abstract

There are a number of genetic factors that likely modulate both the beneficial and adverse effects of estrogen. An important domain of consideration is the relationship of estrogen and thrombosis risk. Gene polymorphisms among the key elements of the coagulation and fibrinolytic cascade appear to influence the effects of estrogen on risk for venous thromboembolic events and possibly arterial thrombosis as well. Emerging data also suggest that allelic variants in the estrogen receptor-alpha may modulate estrogen's effects, especially with respect to bone and lipid metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:34:25