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Titolo:
Flowmetric comparison of respiratory inductance plethysmography and pneumotachography in horses
Autore:
Hoffman, A; Kuehn, H; Riedelberger, K; Kupcinskas, R; Miskovic, MB;
Indirizzi:
Tufts Univ, Sch Vet Med, Dept Clin Sci, North Grafton, MA 01536 USA Tufts Univ North Grafton MA USA 01536 in Sci, North Grafton, MA 01536 USA Vet Univ, Internal Med Clin, A-1210 Vienna, Austria Vet Univ Vienna Austria A-1210 Internal Med Clin, A-1210 Vienna, Austria
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2767 - 2775
SICI:
8750-7587(200112)91:6<2767:FCORIP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; WHOLE-BODY PLETHYSMOGRAPHY; AEROALLERGEN-INDUCED DYSPNEA; AIR-FLOW OBSTRUCTION; GUINEA-PIGS; THORACOABDOMINAL ASYNCHRONY; FORCED OSCILLATION; LUNG-FUNCTION; RIB CAGE; REACTIVITY;
Keywords:
noninvasive; dynamic; resistance; gas compression; heaves;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Hoffman, A Large Anim Med, 200 Westboro Rd, North Grafton, MA 01536 USA Large Anim Med 200 Westboro Rd North Grafton MA USA 01536 6 USA
Citazione:
A. Hoffman et al., "Flowmetric comparison of respiratory inductance plethysmography and pneumotachography in horses", J APP PHYSL, 91(6), 2001, pp. 2767-2775

Abstract

Respiratory inductance plethysmographic (RIP) and pneumotachographic (Pn) flows were compared dynamically in horses with bronchoconstriction. On a breath-by-breath basis, RIP was normalized to inspiratory volume from Pn, andpeak [peak of subtracted final exhalation waveform (SFEmax)] and selected area [integral of subtracted final waveform during first 25% of exhaled volume (SFEint)] differences between RIP and Pn flows during early expiration were measured in three settings: 1) healthy horses (n = 8) undergoing histamine bronchoprovocation; 2) horses with naturally occurring lower airway obstruction (AO) (n = 7); and 3) healthy horses (n = 6) given lobeline . HCl to induce hyperpnea. In setting 1, histamine challenge induced a dose-dependent increase in SFEmax and SFEint differences. A test index of airway reactivity (interpolated histamine dose that increased SFEmax by 35%) closely correlated (r(s) = 0.93, P = 0.001) with a conventional index (histamine dose that induced a 35% decrease in dynamic compliance). In setting 2, in horses with AO, SFEmax and SFEint were markedly elevated, and their absolute values correlated significantly (P < 0.005) with pulmonary resistance and themaximum change in transpulmonary pressure. The effects of bronchodilator treatment on the SFEmax and SFEint were also highly significant (P < 0.0001). In setting 3, hyperpnea, but not tachypnea, caused significant (P < 0.01)increases in SFEmax but not in SFEint. In conclusion, dynamic comparisons between RIP and Pn provide a defensible method for quantifying AO during tidal breathing, without the need for invasive instrumentation.

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Documento generato il 04/12/20 alle ore 12:44:37