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Titolo:
A model of sleep-disordered breathing in the C57BL/6J mouse
Autore:
Tagaito, Y; Polotsky, VY; Campen, MJ; Wilson, JA; Balbir, A; Smith, PL; Schwartz, AR; ODonnell, CP;
Indirizzi:
Johns Hopkins Univ, Dept Med, Div Pulm & Crit Care Med, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 re Med, Baltimore, MD 21224 USA Chiba Univ, Sch Med, Dept Anesthesiol, Chiba 260, Japan Chiba Univ ChibaJapan 260 , Sch Med, Dept Anesthesiol, Chiba 260, Japan
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2758 - 2766
SICI:
8750-7587(200112)91:6<2758:AMOSBI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC EPISODIC HYPOXIA; BLOOD-PRESSURE ELEVATION; OBSTRUCTIVE APNEA; SEDATED PIGS; CARDIOVASCULAR-RESPONSE; RESPIRATORY-FUNCTION; AROUSAL RESPONSES; PERIODIC APNEAS; CANINE MODEL; DOGS;
Keywords:
polysomnography; intermittent hypoxia; arousal; non-rapid eye movement sleep; rapid eye movement sleep;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: O'Donnell, CP Johns Hopkins Asthma & Allergy Ctr, Rm 4B61,5501 Hopkins Bayview Circle, Baltimore, MD 21224 USA Johns Hopkins Asthma & Allergy Ctr Rm 4B61,5501 Hopkins Bayview Circle Baltimore MD USA 21224
Citazione:
Y. Tagaito et al., "A model of sleep-disordered breathing in the C57BL/6J mouse", J APP PHYSL, 91(6), 2001, pp. 2758-2766

Abstract

To investigate the pathophysiological sequelae of sleep-disordered breathing (SDB), we have developed a mouse model in which hypoxia was induced during periods of sleep and was removed in response to arousal or wakefulness. An on-line sleep-wake detection system, based on the frequency and amplitude of electroencephalograph and electromyograph recordings, served to trigger intermittent hypoxia during periods of sleep. In adult male C57BL/6J mice(n = 5), the sleep-wake detection system accurately assessed wakefulness (97.2 +/- 1.1%), non-rapid eye movement (NREM) sleep (96.0 +/- 0.9%) and rapid eye movement (REM) sleep (85.6 +/- 5.0%). After 5 consecutive days of SDB, 554 +/- 29 (SE) hypoxic events were recorded over a 24-h period at a rate of 63.6 +/- 2.6 events/h of sleep and with a duration of 28.2 +/- 0.7 s. The mean nadir of fraction of inspired O-2 (FIo2) on day 5 was 13.2 +/- 0.1%, and 137.1 +/- 13.2 of the events had a nadir FIo2 < 10% O-2. Arterial blood gases confirmed that hypoxia of this magnitude lead to a significant degree of hypoxemia. Furthermore, 5 days of SDB were associated with decreases in both NREM and REM sleep during the light phase compared with the 24-h postintervention period. We conclude that our murine model of SDB mimics the rate and magnitude of sleep-induced hypoxia, sleep fragmentation, and reduction in total sleep time found in patients with moderate to severe SDB inthe clinical setting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 04:23:19