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Titolo:
Overexpression of TGF-alpha increases lung tissue hysteresivity in transgenic mice
Autore:
Pillow, JJ; Korfhagen, TR; Ikegami, M; Sly, PD;
Indirizzi:
TVW Telethon Inst Child Hlth Res, Perth, WA 6872, Australia TVW Telethon Inst Child Hlth Res Perth WA Australia 6872 6872, Australia King Edward & Princess Margaret Hosp, Perth, WA 6840, Australia King Edward & Princess Margaret Hosp Perth WA Australia 6840 0, Australia Childrens Hosp, Med Ctr, Div Pulm Biol, Cincinnati, OH 45229 USA ChildrensHosp Cincinnati OH USA 45229 ulm Biol, Cincinnati, OH 45229 USA Univ Western Australia, Dept Paediat, Subiaco, WA 6008, Australia Univ Western Australia Subiaco WA Australia 6008 iaco, WA 6008, Australia
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2730 - 2734
SICI:
8750-7587(200112)91:6<2730:OOTILT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-ALPHA; BAROMETRIC PLETHYSMOGRAPHY; NONINVASIVE MEASUREMENT; AIRWAY RESPONSIVENESS; EXPRESSION; RATS; STIMULATION; RESISTANCE; IMPEDANCE; FIBROSIS;
Keywords:
pulmonary fibrosis; respiratory mechanics; forced oscillation technique; transforming growth factor-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Pillow, JJ Inst Child Hlth, Portex Unit, 30 Guilford St, London WC1N 1EH, England Inst Child Hlth 30 Guilford St London England WC1N 1EH England
Citazione:
J.J. Pillow et al., "Overexpression of TGF-alpha increases lung tissue hysteresivity in transgenic mice", J APP PHYSL, 91(6), 2001, pp. 2730-2734

Abstract

Increased transforming growth factor (TGF)-alpha has been observed in neonatal chronic lung disease. Lungs of transgenic mice that overexpress TGF-alpha develop enlarged air spaces and pulmonary fibrosis compared with wild-type mice. We hypothesized that these pathological changes may alter the mechanical coupling of viscous and elastic forces within lung parenchyma. Respiratory impedance was measured in open-chested, tracheostomized adult wild-type and TGF-alpha mice by using the forced oscillation technique (0.25-19.63 Hz) delivered by flexiVent (Scireq, Montreal, PQ). Estimates of airway resistance (Raw), inertance (I), and the coefficients of tissue damping (G(L)) and tissue elastance (H-L) were obtained by fitting a model to each impedance spectrum. Hysteresivity (eta) was calculated as G(L)/H-L. There was asignificant increase in eta (P < 0.01) and a trend to a decrease in H-L (P= 0.07) of TGF-<alpha> mice compared with the wild-type group. There was no significant change in Raw, I, or G(L). Structural abnormality present in the lungs of adult TGF-alpha mice alters viscoelastic coupling of the tissues, as evidenced by a change in eta.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:42:44