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Titolo:
On the likelihood of decompression sickness during H-2 biochemical decompression in pigs
Autore:
Fahlman, A; Tikuisis, P; Himm, JF; Weathersby, PK; Kayar, SR;
Indirizzi:
USN, Med Res Ctr, Environm Physiol Dept, Silver Spring, MD 20910 USA USN Silver Spring MD USA 20910 Physiol Dept, Silver Spring, MD 20910 USA Def & Civil Inst Environm Med, Toronto, ON M3M 3B9, Canada Def & Civil Inst Environm Med Toronto ON Canada M3M 3B9 N M3M 3B9, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2720 - 2729
SICI:
8750-7587(200112)91:6<2720:OTLODS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATENT FORAMEN OVALE; COMPLEMENT ACTIVATION; RISK; HYDROGEN; ILLNESS; SWINE; RATS; COMPETITION; SATURATION; BACTERIA;
Keywords:
probabilistic modeling; Sus scrofa; hydrogen diving; H-2 metabolism; Methanobrevibacter smithii;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kayar, SR USN, Med Res Ctr, Environm Physiol Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA USN 503 Robert Grant Ave Silver Spring MD USA 20910 MD 20910 USA
Citazione:
A. Fahlman et al., "On the likelihood of decompression sickness during H-2 biochemical decompression in pigs", J APP PHYSL, 91(6), 2001, pp. 2720-2729

Abstract

A probabilistic model was used to predict decompression sickness (DCS) outcome in pigs during exposures to hyperbaric H-2 to quantify the effects of H-2 biochemical decompression, a process in which metabolism Of H-2 by intestinal microbes facilitates decompression. The data set included 109 exposures to 22-26 atm, ca. 88% H-2, 9% He, 2% O-2, 1% N-2, for 0.5-24 h. Single exponential kinetics described the tissue partial pressures (Ptis) of H-2 and He at time t: Ptis = integral (Pamb - Ptis).tau (-1) dt, where Pamb is ambient pressure and tau is a time constant. The probability of DCS [P(DCS)]was predicted from the risk function: P(DCS) = 1 - e(-r), where r = integral (Ptis(H2) + Ptis(He) - Thr - Pamb).Pamb(-1) dt, and Thr is a threshold parameter. Inclusion of a parameter (A) to estimate the effect of H-2 metabolism on P(DCS): Ptis., = integral (Pamb - A - Ptis(H2)).tau (-1) dt, significantly improved the prediction of P(DCS). Thus lower P(DCS) was predicted by microbial H-2 metabolism during H-2 biochemical decompression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:54:26