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Titolo:
Serotonin elicits long-lasting enhancement of rhythmic respiratory activity in turtle brain stems in vitro
Autore:
Johnson, SM; Wilkerson, JER; Henderson, DR; Wenninger, MR; Mitchell, GS;
Indirizzi:
Univ Wisconsin, Sch Vet Med, Dept Comparat Biosci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 omparat Biosci, Madison, WI 53706 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2703 - 2712
SICI:
8750-7587(200112)91:6<2703:SELEOR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEWBORN RAT; SPINAL-CORD; HYPOGLOSSAL MOTONEURONS; PRESYNAPTIC INHIBITION; VENTILATORY RESPONSE; CERVICAL MOTONEURONS; INSPIRATORY ACTIVITY; IN-VITRO; INVITRO; MODULATION;
Keywords:
control of breathing; respiratory control; plasticity; rhythm generation; reptile; 5-hydroxytryptamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, SM Univ Wisconsin, Sch Vet Med, Dept Comparat Biosci, 2015 LindenDr W, Madison, WI 53706 USA Univ Wisconsin 2015 Linden Dr W Madison WI USA53706 53706 USA
Citazione:
S.M. Johnson et al., "Serotonin elicits long-lasting enhancement of rhythmic respiratory activity in turtle brain stems in vitro", J APP PHYSL, 91(6), 2001, pp. 2703-2712

Abstract

Brain stem preparations from adult turtles were used to determine how bath-applied serotonin (5-HT) alters respiration-related hypoglossal activity in a mature vertebrate. 5-HT (5-20 muM) reversibly decreased integrated burst amplitude by similar to 45% (P < 0.05); burst frequency decreased in a dose-dependent manner with 20 <mu>M abolishing bursts in 9 of 13 preparations(P < 0.05). These 5-HT-dependent effects were mimicked by application of a5-HT1A agonist, but not a 5-HT1B agonist, and were abolished by the broad-spectrum 5-HT antagonist, methiothepin. During 5-HT (20 <mu>M) washout, frequency rebounded to levels above the original baseline for 40 min (P < 0.05) and remained above baseline for 2 h. A 5-HT3 antagonist (tropesitron) blocked the post-5-HT rebound and persistent frequency increase. A 5-HT3 agonist (phenylbiguanide) increased frequency during and after bath application (P < 0.05). When phenylbiguanide was applied to the brain stem of brain stem/spinal cord preparations, there was a persistent frequency increase (P < 0.05), but neither spinal-expiratory nor -inspiratory burst amplitude were altered. The 5-HT3 receptor-dependent persistent frequency increase represents a unique model of plasticity in vertebrate rhythm generation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:34:56