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Titolo:
NO inhalation reduces pulmonary arterial pressure but not hemorrhage in maximally exercising horses
Autore:
Kindig, CA; McDonough, P; Finley, MR; Behnke, BJ; Richardson, TE; Marlin, DJ; Erickson, HH; Poole, DC;
Indirizzi:
Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA Kansas State Univ Manhattan KS USA 66506 Physiol, Manhattan, KS 66506 USA Kansas State Univ, Dept Kinesiol, Manhattan, KS 66506 USA Kansas State Univ Manhattan KS USA 66506 inesiol, Manhattan, KS 66506 USA Anim Hlth Trust, Ctr Equine Studies, Newmarket CB8 7UU, Suffolk, England Anim Hlth Trust Newmarket Suffolk England CB8 7UU 8 7UU, Suffolk, England
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2674 - 2678
SICI:
8750-7587(200112)91:6<2674:NIRPAP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; STRESS FAILURE; BRONCHOALVEOLAR LAVAGE; VASCULAR PRESSURES; BLOOD-FLOW; CAPILLARIES; RACEHORSES; INHIBITION; LUNGS; VASOCONSTRICTION;
Keywords:
bronchoalveolar lavage; exercise-induced pulmonary hemorrhage; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Poole, DC Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA Kansas State Univ Manhattan KS USA 66506 anhattan, KS 66506 USA
Citazione:
C.A. Kindig et al., "NO inhalation reduces pulmonary arterial pressure but not hemorrhage in maximally exercising horses", J APP PHYSL, 91(6), 2001, pp. 2674-2678

Abstract

In horses, the exercise-induced elevation of pulmonary arterial pressure (Ppa) is thought to play a deterministic role in exercise-induced pulmonary hemorrhage (EIPH), and thus treatment designed to lower Ppa might reasonably be expected to reduce EIPH. Five Thoroughbred horses were run on a treadmill to volitional fatigue (incremental step test) under nitric oxide (NO; inhaled 80 ppm) and control (N-2, same flow rate as per NO run) conditions (2 wk between trials; order randomized) to test the hypothesis that NO inhalation would reduce maximal Ppa but that this reduction may not necessarily reduce EIPH. Before each investigation, a microtipped pressure transducer was placed in the pulmonary artery 8 cm past the pulmonic valve to monitor Ppa. EIPH severity was assessed via bronchoalveolar lavage (BAL) 30 min postrun. Exercise time did not differ between the two trials (P > 0.05). NO administration resulted in a small but consistent and significant reduction inpeak Ppa (N-2,102.3 +/- 4.4; NO, 98.6 +/- 4.3 mmHg, P < 0.05). In the faceof lowered Ppa, EIPH severity was significantly higher in the NO trial (N-2, 22.4 +/- 6.8; NO, 42.6 +/- 15.4 x 10(6) red blood cells/ml BAL fluid, P < 0.05). These findings support the notion that extremely high Ppa may reflect, in part, an arteriolar vasoconstriction that serves to protect the capillary bed from the extraordinarily high Ppa evoked during maximal exercisein the Thoroughbred horse. Furthermore, these data suggest that exogenous NO treatment during exercise in horses may not only be poor prophylaxis butmay actually exacerbate the severity of EIPH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:37:07