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Titolo:
Serotonin(2) receptors mediate respiratory recovery after cervical spinal cord hemisection in adult rats
Autore:
Zhou, SY; Basura, GJ; Goshgarian, HG;
Indirizzi:
Wayne State Univ, Sch Med, Dept Anat & Cell Biol, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 & Cell Biol, Detroit, MI 48201 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2665 - 2673
SICI:
8750-7587(200112)91:6<2665:SRMRRA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHRENIC-NERVE ACTIVITY; RAPHE OBSCURUS; NEWBORN RAT; SEROTONERGIC MODULATION; 5-HT2C RECEPTOR; MOTOR NUCLEUS; NEURONS; MOTONEURONS; STIMULATION; CAT;
Keywords:
spinal cord injury; phrenic motoneurons; plasticity; ketanserin; respiration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Goshgarian, HG Wayne State Univ, Sch Med, Dept Anat & Cell Biol, 540 E Canfield Ave, Detroit, MI 48201 USA Wayne State Univ 540 E Canfield Ave Detroit MI USA 48201 SA
Citazione:
S.Y. Zhou et al., "Serotonin(2) receptors mediate respiratory recovery after cervical spinal cord hemisection in adult rats", J APP PHYSL, 91(6), 2001, pp. 2665-2673

Abstract

The aim of the present study was to specifically investigate the involvement of serotonin [5-hydroxytryptamine (5-HT2)] receptors in 5-HT-mediated respiratory recovery after cervical hemisection. Experiments were conducted on C-2 spinal cord-hemisected, anesthetized (chloral hydrate, 400 mg/kg ip),vagotomized, pancuronium-paralyzed, and artificially ventilated female Sprague-Dawley rats in which CO2 levels were monitored and maintained. Twenty-four hours after spinal hemisection, the ipsilateral phrenic nerve displayed no respiratory-related activity indicative of a functionally complete hemisection. Intravenous administration of the 5-HT2A/2C-receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) induced respiratory-related activity in the phrenic nerve ipsilateral to hemisection under conditions in which CO2 was maintained at constant levels and augmented the activity induced under conditions of hypercapnia. The effects of DOI were foundto be dose dependent, and the recovery of activity could be maintained forup to 2 h after a single injection. DOI-induced recovery was attenuated bythe 5-HT2-receptor antagonist ketanserin but not with the 5-HT2C-receptor antagonist RS-102221, suggesting that 5-HT2A and not necessarily 5-HT2C receptors may be involved in the induction of respiratory recovery after cervical spinal cord injury.

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Documento generato il 30/03/20 alle ore 12:29:18