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Titolo:
Multiple mechanisms of reflex bronchospasm in guinea pigs
Autore:
Canning, BJ; Reynolds, SM; Mazzone, SB;
Indirizzi:
Johns Hopkins Asthma & Allergy Ctr, Baltimore, MD 21224 USA Johns Hopkins Asthma & Allergy Ctr Baltimore MD USA 21224 e, MD 21224 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2642 - 2653
SICI:
8750-7587(200112)91:6<2642:MMORBI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITORY NERVOUS-SYSTEM; AIRWAY SMOOTH-MUSCLE; BRADYKININ-INDUCED BRONCHOCONSTRICTION; TACHYKININ RECEPTOR ANTAGONISTS; NITRIC-OXIDE; SENSORY RECEPTORS; FELINE AIRWAYS; SUBSTANCE-P; LUNG; HISTAMINE;
Keywords:
parasympathetic; autonomic; tachykinins; bradykinin; histamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Canning, BJ Johns Hopkins Asthma & Allergy Ctr, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 USA Johns Hopkins Asthma & Allergy Ctr 5501 Hopkins Bayview Circle Baltimore MD USA 21224
Citazione:
B.J. Canning et al., "Multiple mechanisms of reflex bronchospasm in guinea pigs", J APP PHYSL, 91(6), 2001, pp. 2642-2653

Abstract

The mechanisms of histamine- and bradykinin-induced reflex bronchospasm were determined in anesthetized guinea pigs. With intravenous administration,both autacoids evoked dose-dependent increases in trachea cholinergic tone. Vagotomy or atropine prevented these tracheal reflexes. When delivered asan aerosol, bradykinin readily increased tracheal cholinergic tone, whereas histamine aerosols were much less effective at inducing tracheal reflexes. Also, unlike histamine, bradykinin could evoke profound increases in cholinergic tone without directly or indirectly (e.g., prostanoid dependent) inducing measurable airway smooth muscle contraction resulting in bronchospasm. Neither autacoid required de novo synthesis of prostanoids or nitric oxide to induce reflex tracheal contractions. Combined cyclooxygenase inhibition and tachykinin-receptor antagonism did, however, abolish all effects of bradykinin in the airways, whereas responses to histamine were unaffected by these pretreatments. The data indicate that histamine and bradykinin initiate reflex bronchospasm by differential activation of vagal afferent nervesubtypes. We speculate that selective activation of either airway C fibersor airway rapid adapting receptors can initiate reflex bronchospasm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 12:11:20