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Titolo:
Differences between inhaled and intravenous bronchial challenge to detect O-3-induced hyperresponsiveness
Autore:
Sommer, B; Vargas, MH; Chavez, J; Carbajal, V; Segura, P; Montano, LM;
Indirizzi:
Inst Nacl Enfermedades Resp, Dept Invest Asma, Mexico City 14080, DF, Mexico Inst Nacl Enfermedades Resp Mexico City DF Mexico 14080 14080, DF, Mexico Univ Nacl Autonoma Mexico, Fac Med, Dept Farmacol, Mexico City 14080, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 14080 y 14080, DF, Mexico
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2595 - 2601
SICI:
8750-7587(200112)91:6<2595:DBIAIB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED AIRWAY HYPERRESPONSIVENESS; UNANESTHETIZED GUINEA-PIGS; RHESUS-MONKEYS; OZONE; REACTIVITY; BRONCHOCONSTRICTION; PLETHYSMOGRAPHY; RESPONSIVENESS; METHACHOLINE; EPITHELIUM;
Keywords:
ozone; airway hyperresponsiveness; dose-response curve; guinea pig;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Montano, LM Inst Nacl Enfermedades Resp, Dept Invest Asma, Tlalpan 4502, Mexico City 14080, DF, Mexico Inst Nacl Enfermedades Resp Tlalpan 4502 Mexico City DF Mexico 14080
Citazione:
B. Sommer et al., "Differences between inhaled and intravenous bronchial challenge to detect O-3-induced hyperresponsiveness", J APP PHYSL, 91(6), 2001, pp. 2595-2601

Abstract

Ozone (O-3)-induced airway hyperresponsiveness in laboratory animals is usually demonstrated through dose-response curves with inhaled or intravenousbronchoconstrictor agonists. However, comparability of these two routes has not been well documented. Thus guinea pig airway responsiveness to ACh and histamine was evaluated 16-18 h after O-3 (3 parts/million, 1 h) or air exposure by two plethysmographic methods (spontaneously breathing and mechanically ventilated) and by two administration routes (inhalatory or intravenous). We found that O-3 caused airway hyperresponsiveness to intravenous, but not to inhaled, agonists, independent of the plethysmographic method used. Suitability of the inhalatory route to detect airway hyperresponsivenesswas corroborated with inhaled ACh after an antigen challenge or extending O-3 exposure to 3 h. Acetylcholinesterase activity was not modified after O-3 exposure in lung homogenates and blood samples. Thus inhaled agonists were less effective to reveal the airway hyperresponsiveness after an acute O-3 exposure than intravenous ones, at least for the 1-h exposure to 3 parts/million, and this difference seems not to be related to an O-3-induced inhibition of the acetylcholinesterase activity.

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Documento generato il 02/04/20 alle ore 22:15:26