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Titolo:
Methacholine versus histamine: paradoxical response of spirometry and ventilation distribution
Autore:
Verbanck, S; Schuermans, D; Noppen, M; Vincken, W; Paiva, M;
Indirizzi:
Free Univ Brussels, Acad Hosp, Div Resp, B-1090 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1090 esp, B-1090 Brussels, Belgium Free Univ Brussels, Lab Phys Biomed, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 med, B-1070 Brussels, Belgium
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2587 - 2594
SICI:
8750-7587(200112)91:6<2587:MVHPRO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESOLUTION COMPUTED-TOMOGRAPHY; OBSTRUCTIVE PULMONARY-DISEASE; BRONCHIAL REACTIVITY; AIRWAY RESPONSIVENESS; INHALED HISTAMINE; LUNG; BRONCHOCONSTRICTION; CHALLENGE; ASTHMA; COMMUNITY;
Keywords:
bronchoprovocation; airway narrowing; nitrogen washout; parallel heterogeneity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Verbanck, S Free Univ Brussels, Acad Hosp, Div Resp, Laarbeeklaan 101, B-1090 Brussels, Belgium Free Univ Brussels Laarbeeklaan 101 Brussels BelgiumB-1090 m
Citazione:
S. Verbanck et al., "Methacholine versus histamine: paradoxical response of spirometry and ventilation distribution", J APP PHYSL, 91(6), 2001, pp. 2587-2594

Abstract

We investigated the differential effect of histamine and methacholine on spirometry and ventilation distribution (where indexes S-cond and S-acin represent conductive and acinar ventilation heterogeneity; Verbanck S, Schuermans D, Van Muylem A, Noppen M, Paiva M, and Vincken W. J Appl Physiol 83: 1807-1816, 1997). Thirty normal subjects were challenged with cumulative doses of 6.52 mu mol histamine and, on a separate day, with either 6.67 mu molmethacholine (equal-dose group; n = 15) or 13.3 mu mol methacholine (double-dose group; n = 15). Largest average forced expiratory volume in 1 s (FEV1) decreases or S-cond increases obtained in either group were -9% and +286%, respectively; S-acin remained unaffected at all times. In the equal-dosegroup, a smaller FEV1 decline (P = 0.002) after methacholine was paralleled by a smaller S-cond increase (P = 0.041) than with histamine. However, inthe double-dose group, methacholine maintained a smaller FEV1 decline (P =0.009) while inducing a larger S-cond increase (P = 0.006) than did histamine. The differential action of histamine and methacholine is confined to the conductive airways, where histamine likely causes the greatest overall airway narrowing and methacholine induces the largest parallel heterogeneityin airway narrowing, probably at the level of the large and small conductive airways, respectively. The observed ventilation heterogeneities predict a risk for dissociation between ventilation-perfusion mismatch and spirometry, particularly after methacholine challenge.

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Documento generato il 06/04/20 alle ore 02:10:09